A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1

Pbx1 is a homeodomain transcription factor that has the ability to form heterodimers with homeodomain proteins encoded by the homeotic selector (Hox) gene complexes and increase their DNA-binding affinity and specificity. A current hypothesis proposes that interactions with Pbx1 are necessary for Ho...

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Veröffentlicht in:Development (Cambridge) 1997-09, Vol.124 (17), p.3221-3232
Hauptverfasser: McWhirter, J R, Goulding, M, Weiner, J A, Chun, J, Murre, C
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Sprache:eng
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