Modification of Catharanthus roseus alkaloids: a lactone derived from 17-deacetylvinblastine

Abstract A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.

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Bibliographische Detailangaben
Veröffentlicht in:	Planta medica 1989-08, Vol.55 (4), p.364-366
Hauptverfasser:	Bruyn, A. de, Verzele, M, Dejonghe, J.P, Bhushana Rao, K.S.P, Collard, M.P, Trouet, A, Hannart, J
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaloids Animals Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Catharanthus roseus Chemical Phenomena Chemistry Female lactones Lactones - isolation & purification Leukemia P388 - drug therapy Magnetic Resonance Spectroscopy medicinal plants Mice Mice, Inbred DBA Vinblastine - analogs & derivatives Vinblastine - isolation & purification Vinblastine - pharmacology
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Beschreibung
Zusammenfassung:	Abstract A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-962029