Disposition of Minoxidil in Patients with Various Degrees of Renal Function

Disposition of Minoxidil in Patients with Various Degrees of Renal Function

The disposition of minoxidil was evaluated after a 5 mg oral dose in 24 subjects with various degrees of renal function. Patients were divided into four groups based on a 24‐hour ambulatory creatinine clearance (Clcr): Group I (n = 6) Clcr >90 mL/min, Group II (n = 6) Clcr 50–80 mL/min, Group III...

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Veröffentlicht in:Journal of clinical pharmacology 1989-09, Vol.29 (9), p.798-802
Hauptverfasser: Halstenson, Charles E., Opsahl, John A., Wright, C. Eugene, Fleishaker, Joseph C., Andreadis, N. A., Sobieraj, Jadwiga, Matzke, Gary R.
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adult
Antihypertensive agents
Biological and medical sciences
Cardiovascular system
Creatinine - blood
Female
Half-Life
Humans
Kidney Diseases - metabolism
Male
Medical sciences
Middle Aged
Minoxidil - administration & dosage
Minoxidil - pharmacokinetics
Pharmacology. Drug treatments
Urodynamics - drug effects
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Zusammenfassung:The disposition of minoxidil was evaluated after a 5 mg oral dose in 24 subjects with various degrees of renal function. Patients were divided into four groups based on a 24‐hour ambulatory creatinine clearance (Clcr): Group I (n = 6) Clcr >90 mL/min, Group II (n = 6) Clcr 50–80 mL/min, Group III (n = 5) Clcr of 30–49 mL/min, and Group IV (n = 7) Clcr
ISSN:0091-2700
1552-4604
DOI:10.1002/j.1552-4604.1989.tb03422.x