Human B cell lines secreting IgM antibody specific for myelin basic protein

In this study we describe for the first time the production of stable human B cell lines and clones that secrete IgM antibody specific for human myelin basic protein. The technique based on limiting dilutions of Epstein-Barr virus-transformed peripheral B cells from patients with multiple sclerosis,...

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Veröffentlicht in:	Journal of neuroimmunology 1989-09, Vol.24 (1), p.9-16
Hauptverfasser:	Jingwu, Zhang, Lambrechts, Jos, Heyligen, Harry, Vandenbark, Arthur A., Raus, Jef C.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Specificity B-Lymphocytes - immunology Biological and medical sciences Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Viral Clone Cells Epstein-Barr virus transformation Fundamental and applied biological sciences. Psychology Herpesvirus 4, Human - physiology Humans Immunoglobulin M - biosynthesis Immunoglubin M-secreting B lymphoblastoid cell line Kinetics Molecular and cellular biology Myelin basic protein Myelin Basic Protein - immunology
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