Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental Parkinsonism

The effect of transitory blockage of substantia nigra pars compacta glutamatergic inputs by intracranial injections of kynurenic acid were evaluated in two monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The MPTP protocol was designed to mimic the gradual evolution of human...

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Veröffentlicht in:	Neuroscience 1997-11, Vol.81 (2), p.399-404
Hauptverfasser:	Bezard, E, Boraud, T, Bioulac, B, Gross, C.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences compensatory mechanisms Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal glutamate Glutamic Acid - pharmacology Kynurenic Acid - pharmacology Macaca Medical sciences monkey MPTP Neurology Parkinson Disease - drug therapy slow evolution of disease stereotaxic intracranial injection Substantia Nigra - drug effects
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Zusammenfassung:	The effect of transitory blockage of substantia nigra pars compacta glutamatergic inputs by intracranial injections of kynurenic acid were evaluated in two monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The MPTP protocol was designed to mimic the gradual evolution of human Parkinson's disease. No effects were observed before MPTP treatment or in the first stage of treatment. Once clinical signs appeared, however, motor abnormalities were significantly aggravated by blockage of these inputs ( P
ISSN:	0306-4522 1873-7544
DOI:	10.1016/S0306-4522(97)00226-1