5-Fluorouracil Derivatives. XXII. Synthesis and Antitumor Activities of 1-Carbamoyl-5-fluorouracils

Fifty-four 1-carbamoyl-5-fluorouracils were synthesized from 5-fluorouracil and isocyanate or amine. Antitumor activity was tested in the L-1210 tumor system, and 11 compounds gave better values of therapeutic ratio than HCFU (1-hyxylcarbamoyl-5-fluorouracil). 1-(4-Methoxycyclohexylcarbamoyl)-5-fluo...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1997/08/15, Vol.45(8), pp.1372-1375
Hauptverfasser:	OZAKI, Shoichiro, KONG, Xiangzheng, WATANABE, Yutaka, HOSHIKO, Tomonori, KOGA, Toshikazu, OGASAWARA, Tomio, TAKIZAWA, Tsuneharu, FUJISAWA, Hiroshi, IIGO, Masaaki, HOSHI, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(3-methylcyclohexyl)-5-fluorouracil 1-(4-methoxycyclohexyl)-5-fluorouracil 1-carbamoyl-5-fluorouracil 5-fluorouracil Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology antitumor agent Biological and medical sciences Fluorouracil - analogs & derivatives Fluorouracil - chemical synthesis Fluorouracil - pharmacology General aspects Leukemia L1210 - drug therapy Male Medical sciences Mice Mice, Inbred Strains Pharmacology. Drug treatments
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Zusammenfassung:	Fifty-four 1-carbamoyl-5-fluorouracils were synthesized from 5-fluorouracil and isocyanate or amine. Antitumor activity was tested in the L-1210 tumor system, and 11 compounds gave better values of therapeutic ratio than HCFU (1-hyxylcarbamoyl-5-fluorouracil). 1-(4-Methoxycyclohexylcarbamoyl)-5-fluorouracil gave the best result.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.45.1372