Apparent normal phenotype of Fgf6-/- mice

To study the role of the sixth member of the FGF (fibroblast growth factor) family whose expression is restricted to skeletal muscle, we have derived mouse mutants with a homozygous disruption of the Fgf6 gene. The animals are viable, fertile and apparently normal, indicating that FGF6 is not requir...

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Veröffentlicht in:	The International journal of developmental biology 1997-08, Vol.41 (4), p.639-642
Hauptverfasser:	Fiore, F, Planche, J, Gibier, P, Sebille, A, deLapeyrière, O, Birnbaum, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastocyst - metabolism Blotting, Southern Embryonic and Fetal Development Female Fibroblast Growth Factor 6 Fibroblast Growth Factors Gene Targeting - methods Genetic Vectors Genotype Homozygote Lac Operon - genetics Male Mice Mice, Knockout Muscle, Skeletal - embryology Muscle, Skeletal - physiology Phenotype Polymerase Chain Reaction Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Recombination, Genetic Stem Cells - metabolism Transfection
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Beschreibung
Zusammenfassung:	To study the role of the sixth member of the FGF (fibroblast growth factor) family whose expression is restricted to skeletal muscle, we have derived mouse mutants with a homozygous disruption of the Fgf6 gene. The animals are viable, fertile and apparently normal, indicating that FGF6 is not required for vital functions in the laboratory mouse.
ISSN:	0214-6282