Function of the Transplanted Heart: Unique Physiology and Therapeutic Implications

Orthotopic heart transplantation has become an established treatment for selected patients with refractory heart failure. Long-term survival rates are superior to those resulting from other forms of therapy for that patient population. In addition, an improved quality of life has been reported by many patients. However, despite these encouraging results, the transplanted heart does not provide the recipient with normal cardiac function. Cardiac physiology after heart transplantation is unique. Resting hemodynamics differ significantly, acutely and chronically, from those seen in healthy subjects. In addition, neural mechanisms undergo changes as a result of surgical denervation. Afferent control mechanisms and efferent responses both are altered, leading to important clinical abnormalities. Examples include altered cardiovascular responses to exercise, altered cardiac electrophysiology, and altered responses to cardiac pharmacologic agents. An improved understanding of the changes in cardiac physi-ology, which occur after heart transplant, may allow the care of these patients to be optimized