Total Syntheses and Anticholinesterase Activities of (3aS)-N(8)-Norphysostigmine, (3aS)-N(8)-Norphenserine, Their Antipodal Isomers, and Other N(8)-Substituted Analogues
N(8)-Benzylesermethole (6) was prepared from 5-methoxytryptamine (1) in five steps. Resolution of compound 6 by dibenzoyl- and ditoluyltartaric acid provided enantiomers (−)- and (+)-7. After demethylation, reaction with isocyanates and catalytic debenzylation over hydrogen, the total syntheses of (...
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Veröffentlicht in: | Journal of medicinal chemistry 1997-08, Vol.40 (18), p.2895-2901 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | N(8)-Benzylesermethole (6) was prepared from 5-methoxytryptamine (1) in five steps. Resolution of compound 6 by dibenzoyl- and ditoluyltartaric acid provided enantiomers (−)- and (+)-7. After demethylation, reaction with isocyanates and catalytic debenzylation over hydrogen, the total syntheses of (−)- and (+)-N(8)-norphysostigmine [(−)- and (+)-11] and (−)- and (+)-N(8)-norphenserine [(−)- and (+)-12] were accomplished. (−)-N(8)-Norphysostigmine [(−)-11] and (−)-N(8)-norphenserine [(−)-12] were also obtained by transformations of natural physostigmine [(−)-13] and phenserine [(−)-14] prepared from (−)-13. The absolute configurations and optical purity of compounds (−)-11, (−)-12, (+)-11, and (+)-12 were confirmed by a comparison of their optical rotations with those of the compounds synthesized from physostigmine [(−)-13]. The anticholinesterase activities of N(8)-nor- and N(8)-substituted analogues, (−)- and (+)-9, -10, -11, -12, 15, and 16, were compared with those of physostigmine [(−)- and (+)-13] and phenserine [(−)- and (+)-14] and are reported. |
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ISSN: | 0022-2623 1520-4804 |
DOI: | 10.1021/jm970210v |