Value of surveillance cultures in a bone marrow transplantation unit
B. Johan National Institute of Public Health, Gyali u 2-4, H-1097 Budapest, Hungary *Szent László Hospital, Gyali u 5-7, H-1097 Budapest, Hungary National Institute of Haematology, Blood Transfusion, Transplantation and Immunology, Daroczi u24, H-1113 Budapest, Hungary Corresponding author: Dr E. Cz...
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Veröffentlicht in: | Journal of medical microbiology 1997-09, Vol.46 (9), p.785-791 |
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Zusammenfassung: | B. Johan National Institute of Public Health, Gyali u 2-4, H-1097 Budapest, Hungary
*Szent László Hospital, Gyali u 5-7, H-1097 Budapest, Hungary
National Institute of Haematology, Blood Transfusion, Transplantation and Immunology, Daroczi u24, H-1113 Budapest, Hungary
Corresponding author: Dr E. Czirok.
Received April 16, 1996
Revision received February 13, 1997.
Accepted February 13, 1997
Because of the increased risk of infection with the associated diagnostic and therapeutic problems in bone marrow transplantation (BMT) patients, the usefulness of surveillance cultures (SC) at the BMT department of the National Institute of Haematology, Blood Transfusion, Transplantation and Immunology, Budapest, was reviewed. Between January 1992 and May 1995, 26 BMT operations were performed; 13 patients had 23 febrile espisodes. In 12 of these episodes infection was clinically documented; however, SC of these patients yielded bacteria identical with those in the blood culture in only two episodes (1 and 6 days before their blood cultures became positive, respectively). Out of a total of 1187 samples from these patients, potentially pathogenic bacteria were isolated from 145 SC and 43 blood cultures (drawn on 31 different days). Suppression of the gastrointestinal flora could be achieved by the department's decontamination regimen; however, overgrowth by gram-positive organisms (mainly coagulase-negative staphylococci) occurred in the intestine and at other body sites. On the basis of these results, SC are of limited value in predicting infection or identifying the causative organisms of fever. On the other hand, SC are useful in confirming the efficiency of suppression of the body flora by antimicrobial agents. Specific treatment was based on suitably sampled materials, and close contact between physicians, infectious disease specialists and microbiologists was essential. |
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ISSN: | 0022-2615 1473-5644 |
DOI: | 10.1099/00222615-46-9-785 |