Axon regeneration in the Trembler mouse, with mutation affecting Schwann cells

Elongation, branching and regeneration rate of axons are increased (two folds) in Trembler tibial nerve after local freezing and control grafting (NNN; TrTrTr). After chimera transplantation (NTrN), normal regenerating axons are increased by 50% when they grow within a mutant (Tr) as compared to a n...

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Veröffentlicht in:	Comptes rendus de l'Académie des sciences, Série III, Sciences de la vie Série III, Sciences de la vie, 1989, Vol.309 (9), p.377-382
Hauptverfasser:	Ferzaz, B, Koenig, H, Ressouches, A
Format:	Artikel
Sprache:	fre
Schlagworte:	Animals Axons - physiology Freezing Mice Mice, Neurologic Mutants Mutation Nerve Regeneration Schwann Cells Tibial Nerve - physiology Tibial Nerve - transplantation
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Zusammenfassung:	Elongation, branching and regeneration rate of axons are increased (two folds) in Trembler tibial nerve after local freezing and control grafting (NNN; TrTrTr). After chimera transplantation (NTrN), normal regenerating axons are increased by 50% when they grow within a mutant (Tr) as compared to a normal (N) graft. Our results emphasize the influence of the density of Schwann cells and multi-layered basal laminas which characterize Trembler peripheral nerves.
ISSN:	0764-4469