Prevention of urinary retention after general surgery: a controlled trial of carbachol/diazepam versus alfusozine
Background: Postoperative urinary retention is a common complication after surgical procedures. It can cause bladder dilatation, infection, and even sepsis. Carbachol/diazepam and alfusozine have been reported to lower the incidence of postoperative urinary retention, but no study showed the benefit...
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| Veröffentlicht in: | Journal of the American College of Surgeons 1997-09, Vol.185 (3), p.234-236 |
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| container_title | Journal of the American College of Surgeons |
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| creator | Burger, Desiree H.C Kappetein, A.Pieter Boutkan, Herman Breslau, Paul J |
| description | Background:
Postoperative urinary retention is a common complication after surgical procedures. It can cause bladder dilatation, infection, and even sepsis. Carbachol/diazepam and alfusozine have been reported to lower the incidence of postoperative urinary retention, but no study showed the benefits of these drugs in a randomized, placebo-controlled trial.
Study Design:
We used a double blind, placebo-controlled trial in which 249 patients with postoperative urinary retention were randomly assigned to receive carbachol/diazepam (n = 72), alfusozine (n = 82), or placebo (n = 95). The primary endpoint was miction within 2 hours after taking the medication.
Results:
There was no significant difference in miction frequency after taking the medication among the three groups (p = 0.31). The miction rate was 60% for patients in the alfusozine group, 61% in the carbachol/diazepam group, and 51% in the placebo group.
Conclusions:
Alfusozine and carbachol/diazepam had no apparent benefit on the incidence of postoperative urinary retention. |
| doi_str_mv | 10.1016/S1072-7515(01)00921-8 |
| format | Article |
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Postoperative urinary retention is a common complication after surgical procedures. It can cause bladder dilatation, infection, and even sepsis. Carbachol/diazepam and alfusozine have been reported to lower the incidence of postoperative urinary retention, but no study showed the benefits of these drugs in a randomized, placebo-controlled trial.
Study Design:
We used a double blind, placebo-controlled trial in which 249 patients with postoperative urinary retention were randomly assigned to receive carbachol/diazepam (n = 72), alfusozine (n = 82), or placebo (n = 95). The primary endpoint was miction within 2 hours after taking the medication.
Results:
There was no significant difference in miction frequency after taking the medication among the three groups (p = 0.31). The miction rate was 60% for patients in the alfusozine group, 61% in the carbachol/diazepam group, and 51% in the placebo group.
Conclusions:
Alfusozine and carbachol/diazepam had no apparent benefit on the incidence of postoperative urinary retention.</description><identifier>ISSN: 1072-7515</identifier><identifier>EISSN: 1879-1190</identifier><identifier>DOI: 10.1016/S1072-7515(01)00921-8</identifier><identifier>PMID: 9291399</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenergic alpha-Antagonists - therapeutic use ; Aged ; Biological and medical sciences ; Carbachol - therapeutic use ; Diazepam - therapeutic use ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Incidence ; Male ; Medical sciences ; Muscle Relaxants, Central - therapeutic use ; Parasympathomimetics - therapeutic use ; Pharmacology. Drug treatments ; Postoperative Complications - prevention & control ; Quinazolines ; Treatment Failure ; Urinary Retention - etiology ; Urinary Retention - prevention & control ; Urinary system ; Urination - drug effects</subject><ispartof>Journal of the American College of Surgeons, 1997-09, Vol.185 (3), p.234-236</ispartof><rights>1997 American College of Surgeons</rights><rights>1997 INIST-CNRS</rights><rights>Copyright Franklin H. Martin Memorial Foundation Sep 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-e423ed6f6bce93e28c53368eb37b568f9790975fdefcf650a5fe1ad415ca3f6c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1072751501009218$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306,69986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2811115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9291399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burger, Desiree H.C</creatorcontrib><creatorcontrib>Kappetein, A.Pieter</creatorcontrib><creatorcontrib>Boutkan, Herman</creatorcontrib><creatorcontrib>Breslau, Paul J</creatorcontrib><title>Prevention of urinary retention after general surgery: a controlled trial of carbachol/diazepam versus alfusozine</title><title>Journal of the American College of Surgeons</title><addtitle>J Am Coll Surg</addtitle><description>Background:
Postoperative urinary retention is a common complication after surgical procedures. It can cause bladder dilatation, infection, and even sepsis. Carbachol/diazepam and alfusozine have been reported to lower the incidence of postoperative urinary retention, but no study showed the benefits of these drugs in a randomized, placebo-controlled trial.
Study Design:
We used a double blind, placebo-controlled trial in which 249 patients with postoperative urinary retention were randomly assigned to receive carbachol/diazepam (n = 72), alfusozine (n = 82), or placebo (n = 95). The primary endpoint was miction within 2 hours after taking the medication.
Results:
There was no significant difference in miction frequency after taking the medication among the three groups (p = 0.31). The miction rate was 60% for patients in the alfusozine group, 61% in the carbachol/diazepam group, and 51% in the placebo group.
Conclusions:
Alfusozine and carbachol/diazepam had no apparent benefit on the incidence of postoperative urinary retention.</description><subject>Adrenergic alpha-Antagonists - therapeutic use</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carbachol - therapeutic use</subject><subject>Diazepam - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Relaxants, Central - therapeutic use</subject><subject>Parasympathomimetics - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Complications - prevention & control</subject><subject>Quinazolines</subject><subject>Treatment Failure</subject><subject>Urinary Retention - etiology</subject><subject>Urinary Retention - prevention & control</subject><subject>Urinary system</subject><subject>Urination - drug effects</subject><issn>1072-7515</issn><issn>1879-1190</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9rFTEUxQdRalv9CIUgInUxNnfSJJNuRIr_oKCgrkNe5qamzEteb2YetJ_evL6xCzeuEnJ-9-ZwTtOcAH8HHNTZD-C6a7UEecrhLeemg7Z_0hxCr00LYPjTev-LPG-OSrnhHDQ36qA5MJ0BYcxhc_udcItpijmxHNhMMTm6Y4TT8ujChMSuMSG5kZWZrpHuLphjPqeJ8jjiwCaKVavj3tHK-d95PBuiu8eNW7MtUpkLc2OYS76PCV80z4IbC75czuPm16ePPy-_tFffPn-9_HDVeiFgavG8EziooFYejcCu91II1eNK6JVUfTDacKNlGDD4oCR3MiC44RykdyIoL46bN_u9G8q3M5bJrmPxOI4uYZ6L1aZTWgNU8NU_4E2eKVVvtgOAXigjKyT3kKdcCmGwG4rrGpUFbnd92Ic-7C5sy8E-9GH7OneyLJ9Xaxwep5YCqv560V3xNSRyycfyiHV9dQC779_vMayJbSOSLT5i8jhEQj_ZIcf_GPkDEoapNg</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>Burger, Desiree H.C</creator><creator>Kappetein, A.Pieter</creator><creator>Boutkan, Herman</creator><creator>Breslau, Paul J</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>American College of Surgeons</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199709</creationdate><title>Prevention of urinary retention after general surgery: a controlled trial of carbachol/diazepam versus alfusozine</title><author>Burger, Desiree H.C ; Kappetein, A.Pieter ; Boutkan, Herman ; Breslau, Paul J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-e423ed6f6bce93e28c53368eb37b568f9790975fdefcf650a5fe1ad415ca3f6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenergic alpha-Antagonists - therapeutic use</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carbachol - therapeutic use</topic><topic>Diazepam - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Relaxants, Central - therapeutic use</topic><topic>Parasympathomimetics - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Complications - prevention & control</topic><topic>Quinazolines</topic><topic>Treatment Failure</topic><topic>Urinary Retention - etiology</topic><topic>Urinary Retention - prevention & control</topic><topic>Urinary system</topic><topic>Urination - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burger, Desiree H.C</creatorcontrib><creatorcontrib>Kappetein, A.Pieter</creatorcontrib><creatorcontrib>Boutkan, Herman</creatorcontrib><creatorcontrib>Breslau, Paul J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Surgeons</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burger, Desiree H.C</au><au>Kappetein, A.Pieter</au><au>Boutkan, Herman</au><au>Breslau, Paul J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of urinary retention after general surgery: a controlled trial of carbachol/diazepam versus alfusozine</atitle><jtitle>Journal of the American College of Surgeons</jtitle><addtitle>J Am Coll Surg</addtitle><date>1997-09</date><risdate>1997</risdate><volume>185</volume><issue>3</issue><spage>234</spage><epage>236</epage><pages>234-236</pages><issn>1072-7515</issn><eissn>1879-1190</eissn><abstract>Background:
Postoperative urinary retention is a common complication after surgical procedures. It can cause bladder dilatation, infection, and even sepsis. Carbachol/diazepam and alfusozine have been reported to lower the incidence of postoperative urinary retention, but no study showed the benefits of these drugs in a randomized, placebo-controlled trial.
Study Design:
We used a double blind, placebo-controlled trial in which 249 patients with postoperative urinary retention were randomly assigned to receive carbachol/diazepam (n = 72), alfusozine (n = 82), or placebo (n = 95). The primary endpoint was miction within 2 hours after taking the medication.
Results:
There was no significant difference in miction frequency after taking the medication among the three groups (p = 0.31). The miction rate was 60% for patients in the alfusozine group, 61% in the carbachol/diazepam group, and 51% in the placebo group.
Conclusions:
Alfusozine and carbachol/diazepam had no apparent benefit on the incidence of postoperative urinary retention.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9291399</pmid><doi>10.1016/S1072-7515(01)00921-8</doi><tpages>3</tpages></addata></record> |
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| issn | 1072-7515 1879-1190 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenergic alpha-Antagonists - therapeutic use Aged Biological and medical sciences Carbachol - therapeutic use Diazepam - therapeutic use Double-Blind Method Drug Therapy, Combination Female Humans Incidence Male Medical sciences Muscle Relaxants, Central - therapeutic use Parasympathomimetics - therapeutic use Pharmacology. Drug treatments Postoperative Complications - prevention & control Quinazolines Treatment Failure Urinary Retention - etiology Urinary Retention - prevention & control Urinary system Urination - drug effects |
| title | Prevention of urinary retention after general surgery: a controlled trial of carbachol/diazepam versus alfusozine |
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