Polymorphic Antigens in Plasmodium falciparum

A PROMINENT FEATURE of host responses to infection with malaria parasites is an antibody response that includes specificities to a large number of different protein antigens of the asexual blood stages. During the last 5 years, a large number of these antigens have been cloned so that they may be in...

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Veröffentlicht in:	Blood 1989-11, Vol.74 (6), p.1865-1875
Hauptverfasser:	Anders, R.F., Smythe, J.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, Protozoan - genetics Antigens, Protozoan - immunology Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Erythrocytes - parasitology Fundamental and applied biological sciences. Psychology Genes Humans Molecular Sequence Data Plasmodium falciparum - immunology Polymorphism, Genetic Protozoa
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Beschreibung
Zusammenfassung:	A PROMINENT FEATURE of host responses to infection with malaria parasites is an antibody response that includes specificities to a large number of different protein antigens of the asexual blood stages. During the last 5 years, a large number of these antigens have been cloned so that they may be investigated for their potential as components of a malaria vaccine. As a result of the sequencing studies on these cloned genes or gene fragments, a large amount of information has been obtained concerning the primary structural characteristics of Plasmodium falciparum proteins.1
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood.V74.6.1865.1865