Hypoxia-induced changes in radiation sensitivity in human melanoma cells: importance of oxygen-regulated proteins, adenylate energy charge and cell cycle distribution

Hypoxia-induced changes in radiation sensitivity in human melanoma cells: importance of oxygen-regulated proteins, adenylate energy charge and cell cycle distribution

Background and purpose: The effects of transient hypoxia on the radiation sensitivity of human tumour cells have so far been investigated only to a limited extent, and only up to 12 h after reoxygenation. We irradiated cells shortly after reoxygenation (

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Veröffentlicht in:Radiotherapy and oncology 1997-08, Vol.44 (2), p.177-182
Hauptverfasser: Danielsen, Turi, Skøyum, Rubi, Rofstad, Einar K.
Format: Artikel
Sprache:eng
Schlagworte:
Adenylate energy charge
Carrier Proteins - biosynthesis
Cell Cycle
Cell cycle distribution
Cell Hypoxia
Energy Metabolism
Heat-Shock Proteins
HSP70 Heat-Shock Proteins - biosynthesis
Humans
Hypoxia
Melanoma - metabolism
Melanoma - pathology
Melanoma - radiotherapy
Membrane Proteins - biosynthesis
Molecular Chaperones - biosynthesis
Oxygen-regulated proteins
Radiation sensitivity
Radiation Tolerance
Tumor Cells, Cultured
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Zusammenfassung:Background and purpose: The effects of transient hypoxia on the radiation sensitivity of human tumour cells have so far been investigated only to a limited extent, and only up to 12 h after reoxygenation. We irradiated cells shortly after reoxygenation (
ISSN:0167-8140
1879-0887
DOI:10.1016/S0167-8140(97)01929-4