How to express an effect mean as percentage of a control mean?

The expression of effects as % of corresponding controls requires to consider the variance of these controls. Fieller's Theorem allows the appropriate calculation of the deviation of % values. The Zero-Method, which wrongly assumes that the variance of controls is zero, may lead to doubtful int...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 1997-06, Vol.37 (4), p.187-190
Hauptverfasser:	Feuerstein, T.J., Roßner, R., Schumacher, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Analysis of Variance Animals Brain - metabolism Confidence intervals Depolarization-evoked [ 3H]-ACh release Fieller's Theorem Humans Models, Statistical Potassium - pharmacology Rats Ritanserin Ritanserin - pharmacology Serotonin - pharmacology Serotonin Antagonists - pharmacology
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Beschreibung
Zusammenfassung:	The expression of effects as % of corresponding controls requires to consider the variance of these controls. Fieller's Theorem allows the appropriate calculation of the deviation of % values. The Zero-Method, which wrongly assumes that the variance of controls is zero, may lead to doubtful interpretations, as shown with experimental examples on the inhibition of depolarization-evoked transmitter release.
ISSN:	1056-8719 1873-488X
DOI:	10.1016/S1056-8719(97)00017-8