Protein targeting to the yeast vacuole

Mutational and gene fusion studies have identified localization signals that target proteins to the yeast lysosome-like vacuole. Genetic analyses have also identified groups of genes ( VPS and PEP) whose products are required for recognition of these signals, and sorting and transport of proteins to...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 1989-08, Vol.14 (8), p.347-350
Hauptverfasser:	Rothman, Joel H., Yamashiro, Carl T., Kane, Patricia M., Stevens, Tom H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Genes, Fungal Hydrogen-Ion Concentration Mutation Protein Sorting Signals - genetics proteins Proton-Translocating ATPases - metabolism reviews Saccharomyces cerevisiae - metabolism Vacuoles - metabolism Yeasts - genetics Yeasts - metabolism
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Beschreibung
Zusammenfassung:	Mutational and gene fusion studies have identified localization signals that target proteins to the yeast lysosome-like vacuole. Genetic analyses have also identified groups of genes ( VPS and PEP) whose products are required for recognition of these signals, and sorting and transport of proteins to the vacuole. One of the components involved in protein sorting has been shown to be the vacuolar H +-ATPase, presumably via its role in vacuolar acidification.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/0968-0004(89)90170-9