Trisomic 22 placenta in a case of severe intrauterine growth retardation

We describe a case in which a trisomic 22 placenta could be the cause of severe growth retardation in a chromosomally normal female fetus. At amniocentesis a mosaic 46,XX/ 47,XX, +22 was observed in amniotic fluid specimens sampled on two different occasions, while fetal blood from a diagnostic cord...

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Veröffentlicht in:	Prenatal diagnosis 1989-09, Vol.9 (9), p.673-676
Hauptverfasser:	Stioui, S., de Silvestris, M., Molinari, A., Stripparo, L., Ghisoni, L., Simoni, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chorionic villi Chorionic Villi - ultrastructure Chromosomal mosaicism Chromosomes, Human, Pair 22 Female Fetal Growth Retardation - etiology Gynecology. Andrology. Obstetrics Humans Intrauterine growth retardation Karyotyping Management. Prenatal diagnosis Medical sciences Middle Aged Mosaicism Placenta Diseases - complications Placenta Diseases - genetics Pregnancy Pregnancy. Fetus. Placenta Trisomy Trisomy 22
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Beschreibung
Zusammenfassung:	We describe a case in which a trisomic 22 placenta could be the cause of severe growth retardation in a chromosomally normal female fetus. At amniocentesis a mosaic 46,XX/ 47,XX, +22 was observed in amniotic fluid specimens sampled on two different occasions, while fetal blood from a diagnostic cordocentesis revealed a normal chromosome constitution. Postnatal studies showed the consistent presence of trisomic 22 cells in the placenta, while only normal metaphases were found in amnion, blood, and fibroblast cultures.
ISSN:	0197-3851 1097-0223
DOI:	10.1002/pd.1970090911