Differential regulations of matrix metalloproteinases and tissue inhibitors of metalloproteinases in dermal fibroblasts by dibutyril cyclic AMP
The influence of dibutyril cyclic AMP (dbcAMP) on the gene expression of matrix metalloproteinases (MMP)-1, MMP-2, MMP-3, tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 was investigated in human skin fibroblasts by northern analyses. The treatment of dbcAMP increased MMP-1 and MMP-3 mRN...
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| Veröffentlicht in: | Journal of dermatological science 1997-08, Vol.15 (2), p.95-100 |
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| creator | Kuroda, Kei Shinkai, Hiroshi |
| description | The influence of dibutyril cyclic AMP (dbcAMP) on the gene expression of matrix metalloproteinases (MMP)-1, MMP-2, MMP-3, tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 was investigated in human skin fibroblasts by northern analyses. The treatment of dbcAMP increased MMP-1 and MMP-3 mRNA levels but decreased TIMP-1 mRNA levels in time and dose dependent manners. Procollagen α1(I), MMP-2 and TIMP-2 mRNA levels were unaltered by this reagent. Our data indicate that dbcAMP potentially enhances the degradation of extracellular components of connective tissue. |
| doi_str_mv | 10.1016/S0923-1811(97)00035-2 |
| format | Article |
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The treatment of dbcAMP increased MMP-1 and MMP-3 mRNA levels but decreased TIMP-1 mRNA levels in time and dose dependent manners. Procollagen α1(I), MMP-2 and TIMP-2 mRNA levels were unaltered by this reagent. Our data indicate that dbcAMP potentially enhances the degradation of extracellular components of connective tissue.</description><identifier>ISSN: 0923-1811</identifier><identifier>EISSN: 1873-569X</identifier><identifier>DOI: 10.1016/S0923-1811(97)00035-2</identifier><identifier>PMID: 9279690</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Bucladesine - pharmacology ; Cells, Cultured ; Collagen - genetics ; Collagenases - genetics ; dbcAMP ; Extracellular Matrix - enzymology ; Fibroblasts - metabolism ; Gelatinases - genetics ; Gene Expression Regulation, Enzymologic - drug effects ; Glycoproteins - genetics ; Humans ; Matrix Metalloproteinase 1 ; Matrix Metalloproteinase 2 ; Matrix Metalloproteinase 3 - genetics ; Metalloendopeptidases - antagonists & inhibitors ; Metalloendopeptidases - genetics ; MMP ; Protease Inhibitors - metabolism ; Proteins - genetics ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Skin - metabolism ; TIMP ; Tissue Inhibitor of Metalloproteinase-2 ; Tissue Inhibitor of Metalloproteinases ; Up-Regulation - drug effects</subject><ispartof>Journal of dermatological science, 1997-08, Vol.15 (2), p.95-100</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-d5631e7e2111a41a4f0edd7b7aca7d99f8a5906b73e01989d7796577caf88f873</citedby><cites>FETCH-LOGICAL-c389t-d5631e7e2111a41a4f0edd7b7aca7d99f8a5906b73e01989d7796577caf88f873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0923181197000352$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9279690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuroda, Kei</creatorcontrib><creatorcontrib>Shinkai, Hiroshi</creatorcontrib><title>Differential regulations of matrix metalloproteinases and tissue inhibitors of metalloproteinases in dermal fibroblasts by dibutyril cyclic AMP</title><title>Journal of dermatological science</title><addtitle>J Dermatol Sci</addtitle><description>The influence of dibutyril cyclic AMP (dbcAMP) on the gene expression of matrix metalloproteinases (MMP)-1, MMP-2, MMP-3, tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 was investigated in human skin fibroblasts by northern analyses. The treatment of dbcAMP increased MMP-1 and MMP-3 mRNA levels but decreased TIMP-1 mRNA levels in time and dose dependent manners. Procollagen α1(I), MMP-2 and TIMP-2 mRNA levels were unaltered by this reagent. Our data indicate that dbcAMP potentially enhances the degradation of extracellular components of connective tissue.</description><subject>Bucladesine - pharmacology</subject><subject>Cells, Cultured</subject><subject>Collagen - genetics</subject><subject>Collagenases - genetics</subject><subject>dbcAMP</subject><subject>Extracellular Matrix - enzymology</subject><subject>Fibroblasts - metabolism</subject><subject>Gelatinases - genetics</subject><subject>Gene Expression Regulation, Enzymologic - drug effects</subject><subject>Glycoproteins - genetics</subject><subject>Humans</subject><subject>Matrix Metalloproteinase 1</subject><subject>Matrix Metalloproteinase 2</subject><subject>Matrix Metalloproteinase 3 - genetics</subject><subject>Metalloendopeptidases - antagonists & inhibitors</subject><subject>Metalloendopeptidases - genetics</subject><subject>MMP</subject><subject>Protease Inhibitors - metabolism</subject><subject>Proteins - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Skin - metabolism</subject><subject>TIMP</subject><subject>Tissue Inhibitor of Metalloproteinase-2</subject><subject>Tissue Inhibitor of Metalloproteinases</subject><subject>Up-Regulation - drug effects</subject><issn>0923-1811</issn><issn>1873-569X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9KHTEUxkNp0av2EYSspF1Mm8yYyWQlYrUtWBRqobuQSU7aI5mJTTLS-xS-cqP34sZFIZDF-X3nz_cRcsjZB854__E7U23X8IHzd0q-Z4x1omlfkRUfZNeIXv18TVbPyC7Zy_m2QqI9VjtkR7VS9YqtyMMn9B4SzAVNoAl-LcEUjHOm0dPJlIR_6QTFhBDvUiyAs8mQqZkdLZjzAhTn3zhiiWkjecniTB2kqbb3OKY4BpNLpuOaOhyXsk4YqF3bgJaefrs-IG-8CRnebv998uPi_ObsS3N59fnr2ellY7tBlcaJvuMgoeWcm-P6PAPn5CiNNdIp5QcjFOtH2QHjalBO1nuFlNb4YfDVoX1ytOlbN_2zQC56wmwhBDNDXLKWqhWslaKCYgPaFHNO4PVdwsmkteZMPwahn4LQjy5rJfVTELqtusPtgGWcwD2rts7X-smmDvXKe4Sks0WYLThMYIt2Ef8z4R8DiJxS</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Kuroda, Kei</creator><creator>Shinkai, Hiroshi</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Differential regulations of matrix metalloproteinases and tissue inhibitors of metalloproteinases in dermal fibroblasts by dibutyril cyclic AMP</title><author>Kuroda, Kei ; Shinkai, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-d5631e7e2111a41a4f0edd7b7aca7d99f8a5906b73e01989d7796577caf88f873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Bucladesine - pharmacology</topic><topic>Cells, Cultured</topic><topic>Collagen - genetics</topic><topic>Collagenases - genetics</topic><topic>dbcAMP</topic><topic>Extracellular Matrix - enzymology</topic><topic>Fibroblasts - metabolism</topic><topic>Gelatinases - genetics</topic><topic>Gene Expression Regulation, Enzymologic - drug effects</topic><topic>Glycoproteins - genetics</topic><topic>Humans</topic><topic>Matrix Metalloproteinase 1</topic><topic>Matrix Metalloproteinase 2</topic><topic>Matrix Metalloproteinase 3 - genetics</topic><topic>Metalloendopeptidases - antagonists & inhibitors</topic><topic>Metalloendopeptidases - genetics</topic><topic>MMP</topic><topic>Protease Inhibitors - metabolism</topic><topic>Proteins - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Skin - metabolism</topic><topic>TIMP</topic><topic>Tissue Inhibitor of Metalloproteinase-2</topic><topic>Tissue Inhibitor of Metalloproteinases</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuroda, Kei</creatorcontrib><creatorcontrib>Shinkai, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatological science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuroda, Kei</au><au>Shinkai, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential regulations of matrix metalloproteinases and tissue inhibitors of metalloproteinases in dermal fibroblasts by dibutyril cyclic AMP</atitle><jtitle>Journal of dermatological science</jtitle><addtitle>J Dermatol Sci</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>15</volume><issue>2</issue><spage>95</spage><epage>100</epage><pages>95-100</pages><issn>0923-1811</issn><eissn>1873-569X</eissn><abstract>The influence of dibutyril cyclic AMP (dbcAMP) on the gene expression of matrix metalloproteinases (MMP)-1, MMP-2, MMP-3, tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 was investigated in human skin fibroblasts by northern analyses. The treatment of dbcAMP increased MMP-1 and MMP-3 mRNA levels but decreased TIMP-1 mRNA levels in time and dose dependent manners. Procollagen α1(I), MMP-2 and TIMP-2 mRNA levels were unaltered by this reagent. Our data indicate that dbcAMP potentially enhances the degradation of extracellular components of connective tissue.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>9279690</pmid><doi>10.1016/S0923-1811(97)00035-2</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of dermatological science, 1997-08, Vol.15 (2), p.95-100 |
| issn | 0923-1811 1873-569X |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Bucladesine - pharmacology Cells, Cultured Collagen - genetics Collagenases - genetics dbcAMP Extracellular Matrix - enzymology Fibroblasts - metabolism Gelatinases - genetics Gene Expression Regulation, Enzymologic - drug effects Glycoproteins - genetics Humans Matrix Metalloproteinase 1 Matrix Metalloproteinase 2 Matrix Metalloproteinase 3 - genetics Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - genetics MMP Protease Inhibitors - metabolism Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Skin - metabolism TIMP Tissue Inhibitor of Metalloproteinase-2 Tissue Inhibitor of Metalloproteinases Up-Regulation - drug effects |
| title | Differential regulations of matrix metalloproteinases and tissue inhibitors of metalloproteinases in dermal fibroblasts by dibutyril cyclic AMP |
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