Physicochemical properties of enrofloxacin

The physicochemical properties of enrofloxacin, a fluoroquinolone that inhibits the activity of bacterial DNA gyrase, are described. Its spectral, solubility and related physicochemical characteristics are discussed. The dissociation behaviour of enrofloxacin was examined by UV spectrophotometry at...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1997-08, Vol.15 (12), p.1845-1849
Hauptverfasser:	Lizondo, Mònica, Pons, Miquel, Gallardo, Montserrat, Estelrich, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - chemistry Biological and medical sciences Chemical Phenomena Chemistry, Physical Dissociation constants Enrofloxacin Fluorescence Fluoroquinolone Fluoroquinolones General pharmacology Kinetics Medical sciences Partition constants Pharmacology. Drug treatments Physicochemical properties Physicochemical properties. Structure-activity relationships Quinolones - chemistry Solubility Spectrophotometry, Ultraviolet
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Zusammenfassung:	The physicochemical properties of enrofloxacin, a fluoroquinolone that inhibits the activity of bacterial DNA gyrase, are described. Its spectral, solubility and related physicochemical characteristics are discussed. The dissociation behaviour of enrofloxacin was examined by UV spectrophotometry at 25°C in a series of buffers ranging from pH 1 to 10. The corresponding macro- and microscopic dissociation constants were calculated. The apparent n-octanol-water partition coefficients were measured from pH 2 to 10.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/S0731-7085(96)02033-X