Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box

The TATA sequence-binding factor TFIID plays a central role both in promoter activation by RNA polymerase II and other common initiation factors, and in promoter regulation by gene-specific factors. The sequence of yeast TFIID, which seems to be encoded by a single gene, contains interesting structu...

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Veröffentlicht in:Nature (London) 1989-09, Vol.341 (6240), p.299-303
Hauptverfasser: Horikoshi, Masami, Wang, C. Kathy, Fujii, Hiroshi, Cromlish, James A, Weil, P. Anthony, Roeder, Robert G
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Sprache:eng
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Zusammenfassung:The TATA sequence-binding factor TFIID plays a central role both in promoter activation by RNA polymerase II and other common initiation factors, and in promoter regulation by gene-specific factors. The sequence of yeast TFIID, which seems to be encoded by a single gene, contains interesting structural motifs that are possibly involved in these functions, and is similar to sequences of bacterial sigma factors.
ISSN:0028-0836
1476-4687
DOI:10.1038/341299a0