Detection of high levels of immunoreactive human beta-1 interferon in sera from HIV-infected patients

We have examined human interferon beta-1 (HuIFN-β1) levels in the sera from patients with various diseases by using a newly developed highly sensitive enzymelinked immunosorbent assay system (ELISA). High levels of HuIFN-β1 were detected in the sera from Human Immunodeficiency Virus-I (HIV-I) infect...

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Veröffentlicht in:	Life sciences (1973) 1989, Vol.45 (11), p.iii-vii
Hauptverfasser:	Minagawa, Tomonori, Mizuno, Kazuya, Hirano, Seiko, Asano, Misako, Numata, Akihiko, Kohanawa, Masashi, Nakane, Akio, Hachimori, Kei, Tamagawa, Sigenori, Negishi, Masayoshi, Yamazaki, Shojiro, Satoh, Yu-ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS-Related Complex - blood AIDS/HIV Antibodies, Monoclonal Biological and medical sciences Enzyme-Linked Immunosorbent Assay Hepatitis B - blood Hepatitis B - complications HIV Infections - blood HIV Infections - complications HIV Seropositivity - blood Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Interferon Type I - blood Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - complications Medical sciences Pemphigoid, Bullous - blood Pemphigoid, Bullous - complications
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Zusammenfassung:	We have examined human interferon beta-1 (HuIFN-β1) levels in the sera from patients with various diseases by using a newly developed highly sensitive enzymelinked immunosorbent assay system (ELISA). High levels of HuIFN-β1 were detected in the sera from Human Immunodeficiency Virus-I (HIV-I) infected patients, especially of asymptomatic carriers. The serum level of HuIFN-β1 may be a good indicator of HIV-I infection and of other immunological disorders.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(89)90147-1