Dihydrophencomycin Methyl Ester, a New Phenazine Derivative from a Marine Streptomycete
The novel 5, 10-dihydrophencomycin methyl ester (4) and the known microbial metabolites (2-hydroxyphenyl)-acetamide (1), menaquinone MK9 (II, III, VIII, IX-H8) (2), and phencomycin (3a) were isolated from an unidentified marine Streptomyces sp. and the structures were elucidated by NMR methods. Comp...
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| Veröffentlicht in: | Journal of antibiotics 1997/06/25, Vol.50(6), pp.479-483 |
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| container_end_page | 483 |
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| container_issue | 6 |
| container_start_page | 479 |
| container_title | Journal of antibiotics |
| container_volume | 50 |
| creator | PUSECKER, KLAUS LAATSCH, HARTMUT HELMKE, ELISABETH WEYLAND, HORST |
| description | The novel 5, 10-dihydrophencomycin methyl ester (4) and the known microbial metabolites (2-hydroxyphenyl)-acetamide (1), menaquinone MK9 (II, III, VIII, IX-H8) (2), and phencomycin (3a) were isolated from an unidentified marine Streptomyces sp. and the structures were elucidated by NMR methods. Compound 4 shows weak antibiotic activity against Escherichia coll and Bacillus subtilis. |
| doi_str_mv | 10.7164/antibiotics.50.479 |
| format | Article |
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Compound 4 shows weak antibiotic activity against Escherichia coll and Bacillus subtilis.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.50.479</identifier><identifier>PMID: 9268003</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject><![CDATA[Acetanilides - isolation & purification ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics (antibacterial agents, antifungal agents) ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Antibiotics. Antiinfectious agents. 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Antibiot.</addtitle><description>The novel 5, 10-dihydrophencomycin methyl ester (4) and the known microbial metabolites (2-hydroxyphenyl)-acetamide (1), menaquinone MK9 (II, III, VIII, IX-H8) (2), and phencomycin (3a) were isolated from an unidentified marine Streptomyces sp. and the structures were elucidated by NMR methods. Compound 4 shows weak antibiotic activity against Escherichia coll and Bacillus subtilis.</description><subject>Acetanilides - isolation & purification</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics (antibacterial agents, antifungal agents)</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Antibiotics. Antiinfectious agents. 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Antibiot.</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>50</volume><issue>6</issue><spage>479</spage><epage>483</epage><pages>479-483</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>The novel 5, 10-dihydrophencomycin methyl ester (4) and the known microbial metabolites (2-hydroxyphenyl)-acetamide (1), menaquinone MK9 (II, III, VIII, IX-H8) (2), and phencomycin (3a) were isolated from an unidentified marine Streptomyces sp. and the structures were elucidated by NMR methods. Compound 4 shows weak antibiotic activity against Escherichia coll and Bacillus subtilis.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>9268003</pmid><doi>10.7164/antibiotics.50.479</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of Antibiotics, 1997/06/25, Vol.50(6), pp.479-483 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Acetanilides - isolation & purification Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Applied microbiology Bacillus subtilis - drug effects Biological and medical sciences Escherichia coli - drug effects Fermentation Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Marine Medical sciences Microbial Sensitivity Tests Microbiology Pharmacology. Drug treatments Phenazines - chemistry Phenazines - isolation & purification Phenazines - pharmacology Streptomyces Streptomyces - chemistry Streptomyces - metabolism Vitamin K - analogs & derivatives Vitamin K - isolation & purification Vitamin K 2 - analogs & derivatives |
| title | Dihydrophencomycin Methyl Ester, a New Phenazine Derivative from a Marine Streptomycete |
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