Dihydrophencomycin Methyl Ester, a New Phenazine Derivative from a Marine Streptomycete

The novel 5, 10-dihydrophencomycin methyl ester (4) and the known microbial metabolites (2-hydroxyphenyl)-acetamide (1), menaquinone MK9 (II, III, VIII, IX-H8) (2), and phencomycin (3a) were isolated from an unidentified marine Streptomyces sp. and the structures were elucidated by NMR methods. Comp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1997/06/25, Vol.50(6), pp.479-483
Hauptverfasser:	PUSECKER, KLAUS, LAATSCH, HARTMUT, HELMKE, ELISABETH, WEYLAND, HORST
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilides - isolation & purification Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Applied microbiology Bacillus subtilis - drug effects Biological and medical sciences Escherichia coli - drug effects Fermentation Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Marine Medical sciences Microbial Sensitivity Tests Microbiology Pharmacology. Drug treatments Phenazines - chemistry Phenazines - isolation & purification Phenazines - pharmacology Streptomyces Streptomyces - chemistry Streptomyces - metabolism Vitamin K - analogs & derivatives Vitamin K - isolation & purification Vitamin K 2 - analogs & derivatives
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The novel 5, 10-dihydrophencomycin methyl ester (4) and the known microbial metabolites (2-hydroxyphenyl)-acetamide (1), menaquinone MK9 (II, III, VIII, IX-H8) (2), and phencomycin (3a) were isolated from an unidentified marine Streptomyces sp. and the structures were elucidated by NMR methods. Compound 4 shows weak antibiotic activity against Escherichia coll and Bacillus subtilis.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.50.479