EVALUATION OF TUMOUR ANGIOGENESIS AS A PROGNOSTIC MARKER IN MALIGNANT MESOTHELIOMA

EVALUATION OF TUMOUR ANGIOGENESIS AS A PROGNOSTIC MARKER IN MALIGNANT MESOTHELIOMA

Angiogenesis plays an important role in the growth, progression, and metastasis of solid tumours. Malignant mesothelioma (MM) of the pleura is a highly invasive tumour with a poor prognosis. In the present study, microvascular quantification was undertaken on 25 specimens of mesothelioma and 15 spec...

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Veröffentlicht in:The Journal of pathology 1997-06, Vol.182 (2), p.211-216
Hauptverfasser: KUMAR-SINGH, SAMIR, VERMEULEN, PETER B., WEYLER, JOOST, SEGERS, KURT, WEYN, BARBARA, VAN DAELE, ANDRÉ, DIRIX, LUC Y., VAN OOSTEROM, ALLAN T., VAN MARCK, ERIC
Format: Artikel
Sprache:eng
Schlagworte:
angiogenesis
Antigens, CD34 - analysis
Biological and medical sciences
computerized image analysis
Female
Gene Expression
Genes, p53
Humans
Image Processing, Computer-Assisted
Immunohistochemistry
Male
malignant mesothelioma
Medical sciences
Mesothelioma - genetics
Mesothelioma - pathology
Middle Aged
Neovascularization, Pathologic
Platelet Endothelial Cell Adhesion Molecule-1 - analysis
Pleural Neoplasms - genetics
Pleural Neoplasms - pathology
Pneumology
Prognosis
Tumors of the respiratory system and mediastinum
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Zusammenfassung:Angiogenesis plays an important role in the growth, progression, and metastasis of solid tumours. Malignant mesothelioma (MM) of the pleura is a highly invasive tumour with a poor prognosis. In the present study, microvascular quantification was undertaken on 25 specimens of mesothelioma and 15 specimens of non‐neoplastic mesothelium (NNM), by staining for the antigens CD34 and CD31. Areas of highest intratumoural microvascular density (IMD) were identified and counted either manually (mIMD) or on a computerized image analysis system (CIAS; iIMD). The two IMDs were significantly correlated with each other (r=0·736; P
ISSN:0022-3417
1096-9896
DOI:10.1002/(SICI)1096-9896(199706)182:2<211::AID-PATH834>3.0.CO;2-D