The effect of angiotensin II receptor antagonists on kidney function in two-kidney, two-clip Goldblatt hypertensive rats

The effect of blockade of the renin–angiotensin system on kidney function using non-peptide angiotensin AT 1 receptor antagonists was investigated in renovascular hypertensive rats. An angiotensin converting enzyme inhibitor, captopril and two angiotensin AT 1 receptor antagonists, losartan and GR138950 (1-{[3-bromo-2[2-[[(trifluoro-methyl)sulphonyl]amino]phenyl]-5 benzofuranyl]methyl}-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxamide) were administered in Na +-deplete two-kidney, two-clip Goldblatt hypertensive rats over a 3-day period. Captopril, losartan (30 mg/kg body weight) and GR138950 (5 mg/kg body weight) significantly ( P