Isochromosome 12p in mediastinal germ cell tumor

The occurrence of an i(12p) in an extragonadal mediastinal germ cell tumor indicates that this chromosome change, which is characteristic for testicular germ cell tumors, can also occur in germ cell tumors present elsewhere in the body. In addition, the karyotype in this patient was near-diploid, in...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1989-10, Vol.42 (2), p.243-251
Hauptverfasser:	Cin, Paola Dal, Drochmans, Alfons, Moerman, Philippe, Van Den Berghe, Herman
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences chromosome 12 Chromosome Aberrations Chromosome Banding Chromosomes, Human, Pair 12 Dysgerminoma - genetics Dysgerminoma - pathology germ cells Humans Karyotyping Male Mediastinal Neoplasms - genetics Mediastinal Neoplasms - pathology mediastinum Medical sciences Pneumology Tumors of the respiratory system and mediastinum tumours
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Zusammenfassung:	The occurrence of an i(12p) in an extragonadal mediastinal germ cell tumor indicates that this chromosome change, which is characteristic for testicular germ cell tumors, can also occur in germ cell tumors present elsewhere in the body. In addition, the karyotype in this patient was near-diploid, in contrast with testicular germ cell tumors, which as a rule are near-triploid or near-tetraploid.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(89)90092-7