Comparative in vitro activity of lomefloxacin (SC 47111 or NY-198) against fresh clinical bacterial isolates

The in vitro antibacterial activity of a new difluorinated quinolone (lomefloxacin) was compared with that of ten selected antibiotics against 744 fresh bacterial isolates representing 32 species. Lomefloxacin was comparable to other quinolones tested against Enterobacteriaceae (MIC 90, ⩽0.25 μg/ml)...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 1989-05, Vol.12 (3), p.7-11
Hauptverfasser:	Wright, D.N., Saxon, B., Matsen, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Quinolones Anti-Infective Agents - pharmacology Bacteria - drug effects Bacteria - isolation & purification Enterobacteriaceae - drug effects Enterobacteriaceae - isolation & purification Fluoroquinolones Humans Microbial Sensitivity Tests Quinolones
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Beschreibung
Zusammenfassung:	The in vitro antibacterial activity of a new difluorinated quinolone (lomefloxacin) was compared with that of ten selected antibiotics against 744 fresh bacterial isolates representing 32 species. Lomefloxacin was comparable to other quinolones tested against Enterobacteriaceae (MIC 90, ⩽0.25 μg/ml) and generally more effective than other compounds tested against Staphylococcus spp. and Pseudomonas aeruginosa with MIC 90s of ⩽2 and ⩽4 μg/ml, respectively.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/0732-8893(89)90058-8