Persistence of Human Leukocyte Antigen (HLA) Antibodies After One Year in Children Receiving Cryopreserved Valved Allografts

This study shows that the broad anti-HLA antibody response against cryopreserved valved allografts used for surgical repair of congenital heart disease persists beyond 1 year after implantation. In 3 patients, there were clearly defined HLA antibody specificities consistent with the HLA phenotypes o...

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Veröffentlicht in:	The American journal of cardiology 1997-08, Vol.80 (3), p.358-359
Hauptverfasser:	Shaddy, Robert E, Thompson, Dixie D, Osborne, Karen A, Hawkins, John A, Fuller, Thomas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Aortic Valve - transplantation Biological and medical sciences Child Child, Preschool Cryopreservation Epitopes Heart Defects, Congenital - surgery Histocompatibility Antigens Class I - immunology Humans Infant Infant, Newborn Isoantibodies - blood Medical sciences Prospective Studies Pulmonary Valve - transplantation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors Transplantation, Homologous
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Beschreibung
Zusammenfassung:	This study shows that the broad anti-HLA antibody response against cryopreserved valved allografts used for surgical repair of congenital heart disease persists beyond 1 year after implantation. In 3 patients, there were clearly defined HLA antibody specificities consistent with the HLA phenotypes of the patients, i.e., the panel-reactive antibody was directed against major alloantigen groups that were not expressed by the antibody responders.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(97)00366-4