Dissociation of naloxone-sensitive and naloxone-insensitive effects of U-50,488H
This study was designed to compare the dose-related effects of U-50,488H on the cortical electroencephalogram (EEG) and behavior, following either saline or naloxone pretreatment. Adult female Sprague-Dawley rats were implanted with chronic cortical EEG and temporalis muscle electromyographic (EMG)...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1989-05, Vol.33 (1), p.215-217 |
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| creator | Young, Gerald A. |
| description | This study was designed to compare the dose-related effects of U-50,488H on the cortical electroencephalogram (EEG) and behavior, following either saline or naloxone pretreatment. Adult female Sprague-Dawley rats were implanted with chronic cortical EEG and temporalis muscle electromyographic (EMG) recording electrodes and with permanent cannulae in the external jugular vein. U-50,488H injection produced initial “psychotomimetic-like” EEG and behavioral effects for about 10–20 min, followed by a predominance of behavioral stupor and associated EEG slow-wave bursts for about 20 min. Naloxone pretreatment completely antagonized the behavioral stupor and associated EEG slow-wave bursts. However, the “psychotomimetic-like” effects were not antagonized by naloxone pretreatment. Thus, dissociation between naloxone-sensitive and naloxone-insensitive effects of U-50,488H was demonstrated. |
| doi_str_mv | 10.1016/0091-3057(89)90452-8 |
| format | Article |
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Adult female Sprague-Dawley rats were implanted with chronic cortical EEG and temporalis muscle electromyographic (EMG) recording electrodes and with permanent cannulae in the external jugular vein. U-50,488H injection produced initial “psychotomimetic-like” EEG and behavioral effects for about 10–20 min, followed by a predominance of behavioral stupor and associated EEG slow-wave bursts for about 20 min. Naloxone pretreatment completely antagonized the behavioral stupor and associated EEG slow-wave bursts. However, the “psychotomimetic-like” effects were not antagonized by naloxone pretreatment. Thus, dissociation between naloxone-sensitive and naloxone-insensitive effects of U-50,488H was demonstrated.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(89)90452-8</identifier><identifier>PMID: 2780779</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ; Analgesics ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Dissociation ; Dose-Response Relationship, Drug ; Electroencephalography ; Electromyography ; Female ; Medical sciences ; Naloxone - pharmacology ; Naloxone-insensitive ; Naloxone-sensitive ; Neuropharmacology ; Pharmacology. Drug treatments ; Pyrrolidines - pharmacology ; Rats ; Rats, Inbred Strains ; Sleep - drug effects ; U-50,488H</subject><ispartof>Pharmacology, biochemistry and behavior, 1989-05, Vol.33 (1), p.215-217</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2227e436502470818c5cd8dc2f27018562f206d8c59784f75ec35c413bc4b4423</citedby><cites>FETCH-LOGICAL-c417t-2227e436502470818c5cd8dc2f27018562f206d8c59784f75ec35c413bc4b4423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0091305789904528$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6791044$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2780779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Young, Gerald A.</creatorcontrib><title>Dissociation of naloxone-sensitive and naloxone-insensitive effects of U-50,488H</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>This study was designed to compare the dose-related effects of U-50,488H on the cortical electroencephalogram (EEG) and behavior, following either saline or naloxone pretreatment. 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Thus, dissociation between naloxone-sensitive and naloxone-insensitive effects of U-50,488H was demonstrated.</description><subject>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Dissociation</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electroencephalography</subject><subject>Electromyography</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Naloxone - pharmacology</subject><subject>Naloxone-insensitive</subject><subject>Naloxone-sensitive</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrrolidines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sleep - drug effects</subject><subject>U-50,488H</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LHDEUhoNY1q36DxT2QkoLjj3JJHOSm0Kx9QMW7EW9DtnMGYjMJjqZFf33zXaX9U6vEs77vIfDw9gJhwsOvPkOYHhVg8Kv2nwzIJWo9B6bco11pTjiPpvukAP2OecHAJCiwQmbCNSAaKbsz6-Qc_LBjSHFWepm0fXpJUWqMsUcxvBMMxfbt3GIbwF1Hfkxr2v3lYJzqfXNEfvUuT7T8fY9ZPdXv_9e3lTzu-vby5_zykuOYyWEQJJ1o0BIBM21V77VrRedQOBaNeUDTVvGBrXsUJGvVanWCy8XUor6kH3Z7H0c0tOK8miXIXvqexcprbJFI8CgVB-CXNVaN6IuoNyAfkg5D9TZxyEs3fBqOdi1cbvWadc6rTb2v3GrS-10u3-1WFK7K20Vl_xsm7vsXd8NLvqQd1iDhoOUBfuxwahIew402OwDRU9tGIpk26bw_h3_AD7tmf4</recordid><startdate>19890501</startdate><enddate>19890501</enddate><creator>Young, Gerald A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19890501</creationdate><title>Dissociation of naloxone-sensitive and naloxone-insensitive effects of U-50,488H</title><author>Young, Gerald A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2227e436502470818c5cd8dc2f27018562f206d8c59784f75ec35c413bc4b4423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Dissociation</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electroencephalography</topic><topic>Electromyography</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Naloxone - pharmacology</topic><topic>Naloxone-insensitive</topic><topic>Naloxone-sensitive</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrrolidines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sleep - drug effects</topic><topic>U-50,488H</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Young, Gerald A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Young, Gerald A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dissociation of naloxone-sensitive and naloxone-insensitive effects of U-50,488H</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1989-05-01</date><risdate>1989</risdate><volume>33</volume><issue>1</issue><spage>215</spage><epage>217</epage><pages>215-217</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>This study was designed to compare the dose-related effects of U-50,488H on the cortical electroencephalogram (EEG) and behavior, following either saline or naloxone pretreatment. Adult female Sprague-Dawley rats were implanted with chronic cortical EEG and temporalis muscle electromyographic (EMG) recording electrodes and with permanent cannulae in the external jugular vein. U-50,488H injection produced initial “psychotomimetic-like” EEG and behavioral effects for about 10–20 min, followed by a predominance of behavioral stupor and associated EEG slow-wave bursts for about 20 min. Naloxone pretreatment completely antagonized the behavioral stupor and associated EEG slow-wave bursts. However, the “psychotomimetic-like” effects were not antagonized by naloxone pretreatment. Thus, dissociation between naloxone-sensitive and naloxone-insensitive effects of U-50,488H was demonstrated.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2780779</pmid><doi>10.1016/0091-3057(89)90452-8</doi><tpages>3</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1989-05, Vol.33 (1), p.215-217 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer Analgesics Animals Behavior, Animal - drug effects Biological and medical sciences Dissociation Dose-Response Relationship, Drug Electroencephalography Electromyography Female Medical sciences Naloxone - pharmacology Naloxone-insensitive Naloxone-sensitive Neuropharmacology Pharmacology. Drug treatments Pyrrolidines - pharmacology Rats Rats, Inbred Strains Sleep - drug effects U-50,488H |
| title | Dissociation of naloxone-sensitive and naloxone-insensitive effects of U-50,488H |
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