Dissociation of naloxone-sensitive and naloxone-insensitive effects of U-50,488H

This study was designed to compare the dose-related effects of U-50,488H on the cortical electroencephalogram (EEG) and behavior, following either saline or naloxone pretreatment. Adult female Sprague-Dawley rats were implanted with chronic cortical EEG and temporalis muscle electromyographic (EMG)...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1989-05, Vol.33 (1), p.215-217
1. Verfasser: Young, Gerald A.
Format: Artikel
Sprache:eng
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Zusammenfassung:This study was designed to compare the dose-related effects of U-50,488H on the cortical electroencephalogram (EEG) and behavior, following either saline or naloxone pretreatment. Adult female Sprague-Dawley rats were implanted with chronic cortical EEG and temporalis muscle electromyographic (EMG) recording electrodes and with permanent cannulae in the external jugular vein. U-50,488H injection produced initial “psychotomimetic-like” EEG and behavioral effects for about 10–20 min, followed by a predominance of behavioral stupor and associated EEG slow-wave bursts for about 20 min. Naloxone pretreatment completely antagonized the behavioral stupor and associated EEG slow-wave bursts. However, the “psychotomimetic-like” effects were not antagonized by naloxone pretreatment. Thus, dissociation between naloxone-sensitive and naloxone-insensitive effects of U-50,488H was demonstrated.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(89)90452-8