Comparative immunogenicity study of four plasma-derived hepatitis B vaccines in Thai young adults

Immunogenicity of four plasma-derived hepatitis B vaccines (Merck, Sharp and Dohme, Pasteur, Dutch CLB and Korean Cheil-Sugar) was compared in Thai young adults. After primo-immunization, only the Merck and Pasteur vaccines could achieve > 90% seroconversion (i.e. anti-HBs ⩾ 10 mlU ml −1) whereas...

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Veröffentlicht in:	Vaccine 1989-06, Vol.7 (3), p.253-256
Hauptverfasser:	Phanuphak, Praphan, Phanpanich, Taweeporn, Wongurai, Somsong, Sirivichayakul, Sunee, Sriwanthana, Busarawan, Panmuong, Wattana, Utaisen, Oravonna, Chutivongse, Supawat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adults Biological and medical sciences comparative trial Drug Administration Schedule Female Fundamental and applied biological sciences. Psychology Hepatitis B Antibodies - biosynthesis Hepatitis B Vaccines Humans Male Microbiology Thailand Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral Hepatitis Vaccines - administration & dosage Viral Hepatitis Vaccines - adverse effects Viral Hepatitis Vaccines - immunology Virology
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Zusammenfassung:	Immunogenicity of four plasma-derived hepatitis B vaccines (Merck, Sharp and Dohme, Pasteur, Dutch CLB and Korean Cheil-Sugar) was compared in Thai young adults. After primo-immunization, only the Merck and Pasteur vaccines could achieve > 90% seroconversion (i.e. anti-HBs ⩾ 10 mlU ml −1) whereas both the CLB and Korean vaccines needed a fourth dose to achieve this level of seroconversion. The anti-HBs titres of both heat-inactivated vaccines (CLB and Korean) were also significantly lower than those of the other two vaccines. We propose that the HBsAg content in both heat-inactivated vaccines should be increased and a booster (fourth) dose should be given in order to enhance their immunogenicities.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/0264-410X(89)90239-9