Prolonged intestinal afferent nerve discharge in response to cholecystokinin-58 compared to cholecystokinin-8 in rats

Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CC...

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Veröffentlicht in:	Neuroscience letters 1997-07, Vol.230 (2), p.89-92
Hauptverfasser:	Kreis, M.E, Zittel, T.T, Raybould, H.E, Reeve, J.R, Grundy, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent nerve Afferent Pathways - drug effects Afferent Pathways - physiology Animals Benzodiazepinones - pharmacology Biological and medical sciences Cholecystokinin - pharmacology Cholecystokinin physiology Cholecystokinin-58 Cholecystokinin-8 Devazepide Evoked Potentials - drug effects Extrinsic innervation Fundamental and applied biological sciences. Psychology Jejunum - innervation Male Muscle, Smooth - innervation Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Rats Rats, Inbred Strains Sincalide - antagonists & inhibitors Sincalide - pharmacology Small intestine Splanchnic Nerves - drug effects Splanchnic Nerves - physiology Time Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge. Peak discharge frequency was higher for CCK-8 at all doses ( P
ISSN:	0304-3940 1872-7972
DOI:	10.1016/S0304-3940(97)00483-7