Inhibition of normal and psoriatic epidermal phospholipase A2 by picomolar concentrations of recombinant human lipocortin I
SUMMARY Normal human and psoriatic epidermal phospholipase A2 (PLA2) was inhibited by human recombinant lipocortin I when the substrate was present in a several million‐fold molar excess. Inhibition was not total, even at relatively high concentrations of lipocortin I. It is therefore suggested that...
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| Veröffentlicht in: | British journal of dermatology (1951) 1989-08, Vol.121 (2), p.155-160 |
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| container_end_page | 160 |
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| container_issue | 2 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 121 |
| creator | CARTWRIGHT, P.H. ILDERTON, E. SOWDEN, J.M. YARDLEY, H.J. |
| description | SUMMARY
Normal human and psoriatic epidermal phospholipase A2 (PLA2) was inhibited by human recombinant lipocortin I when the substrate was present in a several million‐fold molar excess. Inhibition was not total, even at relatively high concentrations of lipocortin I. It is therefore suggested that human epidermis contains two species of PLA2: one that is controlled by lipocortin I and one that is not. |
| doi_str_mv | 10.1111/j.1365-2133.1989.tb01794.x |
| format | Article |
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Normal human and psoriatic epidermal phospholipase A2 (PLA2) was inhibited by human recombinant lipocortin I when the substrate was present in a several million‐fold molar excess. Inhibition was not total, even at relatively high concentrations of lipocortin I. It is therefore suggested that human epidermis contains two species of PLA2: one that is controlled by lipocortin I and one that is not.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.1989.tb01794.x</identifier><identifier>PMID: 2528367</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Annexins ; Biological and medical sciences ; Calcium-Binding Proteins - pharmacology ; Dermatology ; Dose-Response Relationship, Drug ; Epidermis - drug effects ; Epidermis - enzymology ; Humans ; In Vitro Techniques ; Medical sciences ; Phospholipases - antagonists & inhibitors ; Phospholipases A - antagonists & inhibitors ; Phospholipases A - metabolism ; Phospholipases A2 ; Psoriasis - enzymology ; Psoriasis. Parapsoriasis. Lichen ; Recombinant Proteins - pharmacology</subject><ispartof>British journal of dermatology (1951), 1989-08, Vol.121 (2), p.155-160</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4365-6648dd14d5b76fac7b380d8af205ba7037caa5fe09e0130e17ee96718c7bedf53</citedby><cites>FETCH-LOGICAL-c4365-6648dd14d5b76fac7b380d8af205ba7037caa5fe09e0130e17ee96718c7bedf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.1989.tb01794.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.1989.tb01794.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7352797$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2528367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CARTWRIGHT, P.H.</creatorcontrib><creatorcontrib>ILDERTON, E.</creatorcontrib><creatorcontrib>SOWDEN, J.M.</creatorcontrib><creatorcontrib>YARDLEY, H.J.</creatorcontrib><title>Inhibition of normal and psoriatic epidermal phospholipase A2 by picomolar concentrations of recombinant human lipocortin I</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>SUMMARY
Normal human and psoriatic epidermal phospholipase A2 (PLA2) was inhibited by human recombinant lipocortin I when the substrate was present in a several million‐fold molar excess. Inhibition was not total, even at relatively high concentrations of lipocortin I. It is therefore suggested that human epidermis contains two species of PLA2: one that is controlled by lipocortin I and one that is not.</description><subject>Annexins</subject><subject>Biological and medical sciences</subject><subject>Calcium-Binding Proteins - pharmacology</subject><subject>Dermatology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epidermis - drug effects</subject><subject>Epidermis - enzymology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Phospholipases - antagonists & inhibitors</subject><subject>Phospholipases A - antagonists & inhibitors</subject><subject>Phospholipases A - metabolism</subject><subject>Phospholipases A2</subject><subject>Psoriasis - enzymology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Recombinant Proteins - pharmacology</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUF1v0zAUtRBolMFPQLIQ4i3Bjus44QFpDCidpvFQ0B6tG8dRXRI7s1PRan8em0Z9nyXLks_Hvecg9I6SnMbzcZdTVvKsoIzltK7qfGoIFfUyPzxDizP0HC0IISIjdcleolch7AihjHBygS4KXlSsFAv0uLZb05jJOItdh63zA_QYbIvH4LyBySisR9Pq___j1oV4ezNC0PiqwM0Rj0a5wfXgsXJWaTt5SG4h2XkdscZYsBPe7gewOEqdcn4yFq9foxcd9EG_md9L9Pv7t1_XP7Lbn6v19dVtppYpS1kuq7aly5Y3ouxAiYZVpK2gKwhvQBAmFADvNKl1yqep0LouBa0iU7cdZ5fow8l39O5hr8MkBxOU7nuw2u2DFHV04ryKxE8novIuBK87OXozgD9KSmRqXu5kqlememVqXs7Ny0MUv52n7JtBt2fpXHXE3884BAV958EqE840wXgh6kT7fKL9Nb0-PmEB-eXmK-UpbXYyMGHSh7MB-D8ybiG4vL9byc2m3gi2uZcr9g-LTbI7</recordid><startdate>198908</startdate><enddate>198908</enddate><creator>CARTWRIGHT, P.H.</creator><creator>ILDERTON, E.</creator><creator>SOWDEN, J.M.</creator><creator>YARDLEY, H.J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198908</creationdate><title>Inhibition of normal and psoriatic epidermal phospholipase A2 by picomolar concentrations of recombinant human lipocortin I</title><author>CARTWRIGHT, P.H. ; ILDERTON, E. ; SOWDEN, J.M. ; YARDLEY, H.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4365-6648dd14d5b76fac7b380d8af205ba7037caa5fe09e0130e17ee96718c7bedf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Annexins</topic><topic>Biological and medical sciences</topic><topic>Calcium-Binding Proteins - pharmacology</topic><topic>Dermatology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epidermis - drug effects</topic><topic>Epidermis - enzymology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Phospholipases - antagonists & inhibitors</topic><topic>Phospholipases A - antagonists & inhibitors</topic><topic>Phospholipases A - metabolism</topic><topic>Phospholipases A2</topic><topic>Psoriasis - enzymology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Recombinant Proteins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CARTWRIGHT, P.H.</creatorcontrib><creatorcontrib>ILDERTON, E.</creatorcontrib><creatorcontrib>SOWDEN, J.M.</creatorcontrib><creatorcontrib>YARDLEY, H.J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CARTWRIGHT, P.H.</au><au>ILDERTON, E.</au><au>SOWDEN, J.M.</au><au>YARDLEY, H.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of normal and psoriatic epidermal phospholipase A2 by picomolar concentrations of recombinant human lipocortin I</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1989-08</date><risdate>1989</risdate><volume>121</volume><issue>2</issue><spage>155</spage><epage>160</epage><pages>155-160</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>SUMMARY
Normal human and psoriatic epidermal phospholipase A2 (PLA2) was inhibited by human recombinant lipocortin I when the substrate was present in a several million‐fold molar excess. Inhibition was not total, even at relatively high concentrations of lipocortin I. It is therefore suggested that human epidermis contains two species of PLA2: one that is controlled by lipocortin I and one that is not.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2528367</pmid><doi>10.1111/j.1365-2133.1989.tb01794.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 1989-08, Vol.121 (2), p.155-160 |
| issn | 0007-0963 1365-2133 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79205558 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Annexins Biological and medical sciences Calcium-Binding Proteins - pharmacology Dermatology Dose-Response Relationship, Drug Epidermis - drug effects Epidermis - enzymology Humans In Vitro Techniques Medical sciences Phospholipases - antagonists & inhibitors Phospholipases A - antagonists & inhibitors Phospholipases A - metabolism Phospholipases A2 Psoriasis - enzymology Psoriasis. Parapsoriasis. Lichen Recombinant Proteins - pharmacology |
| title | Inhibition of normal and psoriatic epidermal phospholipase A2 by picomolar concentrations of recombinant human lipocortin I |
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