Inhibition of normal and psoriatic epidermal phospholipase A2 by picomolar concentrations of recombinant human lipocortin I

SUMMARY Normal human and psoriatic epidermal phospholipase A2 (PLA2) was inhibited by human recombinant lipocortin I when the substrate was present in a several million‐fold molar excess. Inhibition was not total, even at relatively high concentrations of lipocortin I. It is therefore suggested that...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of dermatology (1951) 1989-08, Vol.121 (2), p.155-160
Hauptverfasser:	CARTWRIGHT, P.H., ILDERTON, E., SOWDEN, J.M., YARDLEY, H.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexins Biological and medical sciences Calcium-Binding Proteins - pharmacology Dermatology Dose-Response Relationship, Drug Epidermis - drug effects Epidermis - enzymology Humans In Vitro Techniques Medical sciences Phospholipases - antagonists & inhibitors Phospholipases A - antagonists & inhibitors Phospholipases A - metabolism Phospholipases A2 Psoriasis - enzymology Psoriasis. Parapsoriasis. Lichen Recombinant Proteins - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	SUMMARY Normal human and psoriatic epidermal phospholipase A2 (PLA2) was inhibited by human recombinant lipocortin I when the substrate was present in a several million‐fold molar excess. Inhibition was not total, even at relatively high concentrations of lipocortin I. It is therefore suggested that human epidermis contains two species of PLA2: one that is controlled by lipocortin I and one that is not.
ISSN:	0007-0963 1365-2133
DOI:	10.1111/j.1365-2133.1989.tb01794.x