Effect of chronic clozapine administration on [ 3H]MK801-binding sites in the rat brain: a side-preference action in cortical areas

We studied modifications in [ 3H]MK801-binding sites in the rat brain after chronic clozapine. We found a 20–30% reduction of [ 3H]MK801-binding sites in the anterior cingulate, frontoparietal motor and frontoparietal somatosensory cortices on the left side but none on the right. We also demonstrate...

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Veröffentlicht in:	Brain research 1997-07, Vol.762 (1), p.216-218
Hauptverfasser:	Giardino, Luciana, Bortolotti, Francesca, Orazzo, Catello, Pozza, Monica, Monteleone, Palmiero, Calzà, Laura, Maj, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 3H]MK801 Animals Antipsychotic Agents - pharmacology Autoradiography Binding Sites - physiology Brain Chemistry - physiology Cerebral Cortex - chemistry Cerebral Cortex - metabolism Clozapine Clozapine - pharmacology Dizocilpine Maleate - metabolism Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - metabolism Excitatory Amino Acid Antagonists - pharmacology Male N-Methyl- d-aspartate (NMDA) receptor Quantitative receptor autoradiography Rat Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Time Factors Tritium
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Zusammenfassung:	We studied modifications in [ 3H]MK801-binding sites in the rat brain after chronic clozapine. We found a 20–30% reduction of [ 3H]MK801-binding sites in the anterior cingulate, frontoparietal motor and frontoparietal somatosensory cortices on the left side but none on the right. We also demonstrated a 20% bilateral increase of N-methyl- d-aspartate (NMDA) receptors in the dentate gyrus of the hippocampus. No changes were found in the prefrontal cortex, caudate-putamen, nucleus accumbens, hippocampus or olfactory tubercle.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(97)00478-2