FeLV-FAIDS-induced immunodeficiency syndrome in cats

Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which p...

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Veröffentlicht in:	Veterinary immunology and immunopathology 1989-05, Vol.21 (1), p.25-37
Hauptverfasser:	Mullins, James I., Hoover, Edward A., Overbaugh, Julie, Quackenbush, Sandra L., Donahue, Peter R., Poss, Mary L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome AIDS/HIV Animals Cat Diseases - immunology Cat Diseases - microbiology Cats Disease Models, Animal feline leukemia virus Genes, Viral Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - microbiology Immunologic Deficiency Syndromes - veterinary Leukemia - immunology Leukemia - microbiology Leukemia - veterinary Leukemia Virus, Feline - genetics Leukemia Virus, Feline - immunology Leukemia Virus, Feline - isolation & purification Leukemia Virus, Feline - pathogenicity Retroviridae Infections - immunology Retroviridae Infections - microbiology Retroviridae Infections - veterinary
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Beschreibung
Zusammenfassung:	Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).
ISSN:	0165-2427 1873-2534
DOI:	10.1016/0165-2427(89)90127-X