Isolation of Flavonoids and a Chalcone from Helichrysum odoratissimum and Synthesis of Helichrysetin

3,5-Dihydroxy-6,7,8-trimethoxyflavone, 3-O-methylquercetin, and helichrysetin were isolated from the flowers of the Rwandese medicinal plant, Helichrysum odoratissimum. Because of inconsistencies of the mp of the latter chalcone, a synthesis of helichrysetin was developed. 3-O-Methylquercetin was sh...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1989-05, Vol.52 (3), p.629-633
Hauptverfasser:	Van Puyvelde, Luc, De Kimpe, Norbert, Costa, Jean, Munyjabo, Viateur, Nyirankuliza, Speciosa, Hakizamungu, Etienne, Schamp, Niceas
Format:	Artikel
Sprache:	eng
Schlagworte:	AISLAMIENTO (TECNICA) Anti-Infective Agents - chemical synthesis Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology ANTIMICROBIALS ANTIMICROBIANO ANTIMICROBIEN Chalcone - analogs & derivatives Chalcone - biosynthesis Chalcone - chemical synthesis Chalcone - isolation & purification COMPOSITAE FLAVONOIDE FLAVONOIDES FLAVONOIDS Flavonoids - isolation & purification ISOLATION ISOLEMENT Microbial Sensitivity Tests Plants, Medicinal - analysis Propiophenones - biosynthesis Propiophenones - isolation & purification
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Zusammenfassung:	3,5-Dihydroxy-6,7,8-trimethoxyflavone, 3-O-methylquercetin, and helichrysetin were isolated from the flowers of the Rwandese medicinal plant, Helichrysum odoratissimum. Because of inconsistencies of the mp of the latter chalcone, a synthesis of helichrysetin was developed. 3-O-Methylquercetin was shown to be an active principle as it displayed antimicrobial activity.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50063a025