Effect of Sizofilan, an Immunomodulator, on Hepatic Microsomal Mixed-Function Oxidase Activities in Rats
Mixed-function oxidase activities of hepatic microsomal preparations from rats were examined after intraperitoneal administration of sizofilan (SPG), an immunomodulator. Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-...
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| Veröffentlicht in: | Japanese Journal of Pharmacology 1989, Vol.50(4), pp.499-502 |
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| container_end_page | 502 |
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| container_issue | 4 |
| container_start_page | 499 |
| container_title | Japanese Journal of Pharmacology |
| container_volume | 50 |
| creator | YOMOGIDA, Shin KOIWAI, Kimiko SHIBA, Yoshihiro ISHIKAWA, Masaaki TAKAYANAGI, Yoshio SASAKI, Ken-ichi |
| description | Mixed-function oxidase activities of hepatic microsomal preparations from rats were examined after intraperitoneal administration of sizofilan (SPG), an immunomodulator. Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-demethylase and aniline hydroxylase. |
| doi_str_mv | 10.1254/jjp.50.499 |
| format | Article |
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Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-demethylase and aniline hydroxylase.</description><identifier>ISSN: 0021-5198</identifier><identifier>EISSN: 1347-3506</identifier><identifier>DOI: 10.1254/jjp.50.499</identifier><identifier>PMID: 2528647</identifier><identifier>CODEN: JJPAAZ</identifier><language>eng</language><publisher>Kyoto: The Japanese Pharmacological Society</publisher><subject>Aminopyrine N-Demethylase - antagonists & inhibitors ; Aniline Compounds - metabolism ; Aniline Hydroxylase - antagonists & inhibitors ; Animals ; Antipyrine - metabolism ; Biological and medical sciences ; Cytochrome P-450 Enzyme Inhibitors ; Glycosaminoglycans - pharmacology ; Immunomodulators ; Immunosuppressive Agents - pharmacology ; In Vitro Techniques ; Injections, Intraperitoneal ; Male ; Medical sciences ; Microsomes, Liver - drug effects ; Microsomes, Liver - enzymology ; Mixed Function Oxygenases - antagonists & inhibitors ; Mixed Function Oxygenases - metabolism ; Pharmacology. 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Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-demethylase and aniline hydroxylase.</description><subject>Aminopyrine N-Demethylase - antagonists & inhibitors</subject><subject>Aniline Compounds - metabolism</subject><subject>Aniline Hydroxylase - antagonists & inhibitors</subject><subject>Animals</subject><subject>Antipyrine - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cytochrome P-450 Enzyme Inhibitors</subject><subject>Glycosaminoglycans - pharmacology</subject><subject>Immunomodulators</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsomes, Liver - drug effects</subject><subject>Microsomes, Liver - enzymology</subject><subject>Mixed Function Oxygenases - antagonists & inhibitors</subject><subject>Mixed Function Oxygenases - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sizofiran - pharmacology</subject><issn>0021-5198</issn><issn>1347-3506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtv1DAUhS0EKtPChj1SFohF1Qx-O1lWpUMrFVXisbYcPxhHiR3sBBV-PR4yzMb20f10fO-5ALxBcIswox_6ftoyuKVt-wxsEKGiJgzy52ADIUY1Q23zEpzn3BfZQETPwBlmuOFUbMD-1jmr5yq66qv_E50fVLiqVKjux3EJcYxmGdQc01UVQ3VnJzV7XX32OsUcRzWU55M19W4JevaFeHzyRmVbXRf5y8_e5sqH6oua8yvwwqkh29fH-wJ8391-u7mrHx4_3d9cP9SaQzzXDhvCVWOg0IYKQiFHQmjNLGq40NB0sOtawqlDjjhDmWCEGCUsNp1jolHkArxffacUfy42z3L0WduhzGXjkqVoUdsiwQt4uYKHWXKyTk7Jjyr9lgjKQ6yyxCoZlCXWAr89ui7daM0JPeZY6u-OdZW1GlxSQft8wrhgmGBYsN2KFQ9fuBgGH6zs45JCCUVqx_s-ToMsK2slhAxCKiESEpYmZJG4EZyJQz8fV6M-z-qHPX2kUtnPUBynfUYtQ__6X4-Dw_-y3qskbSB_AbBKrrQ</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>YOMOGIDA, Shin</creator><creator>KOIWAI, Kimiko</creator><creator>SHIBA, Yoshihiro</creator><creator>ISHIKAWA, Masaaki</creator><creator>TAKAYANAGI, Yoshio</creator><creator>SASAKI, Ken-ichi</creator><general>The Japanese Pharmacological Society</general><general>Japanese Pharmacological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Effect of Sizofilan, an Immunomodulator, on Hepatic Microsomal Mixed-Function Oxidase Activities in Rats</title><author>YOMOGIDA, Shin ; KOIWAI, Kimiko ; SHIBA, Yoshihiro ; ISHIKAWA, Masaaki ; TAKAYANAGI, Yoshio ; SASAKI, Ken-ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-f2d36a8d07cd473406177cc5e1867c0db0bb9364f1f3fd457533da7e2dbf578a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aminopyrine N-Demethylase - antagonists & inhibitors</topic><topic>Aniline Compounds - metabolism</topic><topic>Aniline Hydroxylase - antagonists & inhibitors</topic><topic>Animals</topic><topic>Antipyrine - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cytochrome P-450 Enzyme Inhibitors</topic><topic>Glycosaminoglycans - pharmacology</topic><topic>Immunomodulators</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsomes, Liver - drug effects</topic><topic>Microsomes, Liver - enzymology</topic><topic>Mixed Function Oxygenases - antagonists & inhibitors</topic><topic>Mixed Function Oxygenases - metabolism</topic><topic>Pharmacology. 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| identifier | ISSN: 0021-5198 |
| ispartof | The Japanese Journal of Pharmacology, 1989, Vol.50(4), pp.499-502 |
| issn | 0021-5198 1347-3506 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79199176 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Aminopyrine N-Demethylase - antagonists & inhibitors Aniline Compounds - metabolism Aniline Hydroxylase - antagonists & inhibitors Animals Antipyrine - metabolism Biological and medical sciences Cytochrome P-450 Enzyme Inhibitors Glycosaminoglycans - pharmacology Immunomodulators Immunosuppressive Agents - pharmacology In Vitro Techniques Injections, Intraperitoneal Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mixed Function Oxygenases - antagonists & inhibitors Mixed Function Oxygenases - metabolism Pharmacology. Drug treatments Rats Rats, Inbred Strains Sizofiran - pharmacology |
| title | Effect of Sizofilan, an Immunomodulator, on Hepatic Microsomal Mixed-Function Oxidase Activities in Rats |
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