Effect of Sizofilan, an Immunomodulator, on Hepatic Microsomal Mixed-Function Oxidase Activities in Rats

Mixed-function oxidase activities of hepatic microsomal preparations from rats were examined after intraperitoneal administration of sizofilan (SPG), an immunomodulator. Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1989, Vol.50(4), pp.499-502
Hauptverfasser:	YOMOGIDA, Shin, KOIWAI, Kimiko, SHIBA, Yoshihiro, ISHIKAWA, Masaaki, TAKAYANAGI, Yoshio, SASAKI, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyrine N-Demethylase - antagonists & inhibitors Aniline Compounds - metabolism Aniline Hydroxylase - antagonists & inhibitors Animals Antipyrine - metabolism Biological and medical sciences Cytochrome P-450 Enzyme Inhibitors Glycosaminoglycans - pharmacology Immunomodulators Immunosuppressive Agents - pharmacology In Vitro Techniques Injections, Intraperitoneal Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mixed Function Oxygenases - antagonists & inhibitors Mixed Function Oxygenases - metabolism Pharmacology. Drug treatments Rats Rats, Inbred Strains Sizofiran - pharmacology
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Zusammenfassung:	Mixed-function oxidase activities of hepatic microsomal preparations from rats were examined after intraperitoneal administration of sizofilan (SPG), an immunomodulator. Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-demethylase and aniline hydroxylase.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.50.499