High-Performance Liquid Chromatographic Assay of Diltiazem and Six of Its Metabolites in Plasma: Application to a Pharmacokinetic Study in Healthy Volunteers

A sensitive and specific reversed-phase high-performance liquid chromatographic assay for simultaneous determination of plasma concentrations of diltiazem and six of its metabolites known to occur in humans is reported. Using 2 mL of plasma, the lower limit of quantitation of the assay was

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Veröffentlicht in:	Journal of pharmaceutical sciences 1989-07, Vol.78 (7), p.592-597
Hauptverfasser:	Yeung, Pollen K.F., Montague, Terrence J., Tsui, Ban, McGregor, Carl
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Analysis Biological and medical sciences Biotransformation Chromatography, High Pressure Liquid Diltiazem - blood Diltiazem - metabolism Diltiazem - pharmacokinetics Female General pharmacology Humans Male Medical sciences Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	A sensitive and specific reversed-phase high-performance liquid chromatographic assay for simultaneous determination of plasma concentrations of diltiazem and six of its metabolites known to occur in humans is reported. Using 2 mL of plasma, the lower limit of quantitation of the assay was
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600780718