Ethacizin Metabolism in Humans

1. The major metabolites of ethacizin (ethyl 10-[3-diethylaminopropionyl]pheno-thiazine-2-carbamate) have been isolated from human urine by h.p.l.c. and identified by determination of u.v., i.r., n.m.r. and mass spectra and comparison with spectra of synthetic standard compounds. 2. The pathways of...

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Veröffentlicht in:	Xenobiotica 1989, Vol.19 (7), p.755-767
Hauptverfasser:	Beloborodov, V. L., Rodionov, A. P., Tyukavkina, N. A., Klimov, A. V., Kaverina, N. V., Kolesnik, YU. A., Gritsenko, A. N., Lesina, V. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Arrhythmia Agents - metabolism Anti-Arrhythmia Agents - urine Biological and medical sciences Biotransformation Cardiovascular system Chromatography, High Pressure Liquid Humans Hydrolysis Medical sciences Miscellaneous Oxidation-Reduction Pharmacology. Drug treatments Phenothiazines - metabolism Phenothiazines - urine
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Zusammenfassung:	1. The major metabolites of ethacizin (ethyl 10-[3-diethylaminopropionyl]pheno-thiazine-2-carbamate) have been isolated from human urine by h.p.l.c. and identified by determination of u.v., i.r., n.m.r. and mass spectra and comparison with spectra of synthetic standard compounds. 2. The pathways of metabolism of ethacizin include N-de-ethylation, sulphoxidation, N-10 amide hydrolysis, aromatic hydroxylation and conjugation.
ISSN:	0049-8254 1366-5928
DOI:	10.3109/00498258909042313