The influence of the convulsant pentylenetetrazol on Ca2+-selective microelectrodes (neutral carrier ETH 1001)

Interference of the epileptogenic drug pentylenetetrazol (PTZ) on the Ca2+-selective microelectrode based on the neutral carrier ETH 1001 is described. It is suggested that tetraphenylborate, a component of the Ca2+-selective membrane, is responsible for this interference. Though the sensitivity of...

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Veröffentlicht in:	Journal of neuroscience methods 1989-08, Vol.29 (2), p.139-142
Hauptverfasser:	LÜCKE, A, LEHMENKÜHLER, A, SPECKMANN, E. -J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - physiology Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Microelectrodes Pentylenetetrazole - pharmacology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Interference of the epileptogenic drug pentylenetetrazol (PTZ) on the Ca2+-selective microelectrode based on the neutral carrier ETH 1001 is described. It is suggested that tetraphenylborate, a component of the Ca2+-selective membrane, is responsible for this interference. Though the sensitivity of the Ca2+-selective microelectrode to PTZ is low, the error in measurements of the free Ca2+ concentration in biological preparations treated with PTZ has to be considered, since pathological changes in the extracellular Ca2+ concentration also produce relatively small changes in the relative electrode potential.
ISSN:	0165-0270 1872-678X
DOI:	10.1016/0165-0270(89)90025-3