New Indole Derivatives with Free Radical Scavenging Activity from Agrocybe cylindracea

Two new indole derivatives were isolated as free radical scavengers from the MeOH extract of Agrocybe cylindracea. The structures of these compounds were determined to be 6-hydroxy-1H-indole-3-carboxaldehyde (1) and 6-hydroxy-1H-indole-3-acetamide (2) on the basis of spectroscopic studies. Compounds...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-07, Vol.60 (7), p.721-723
Hauptverfasser:	Kim, Won-Gon, Lee, In-Kyoung, Kim, Jong-Pyung, Ryoo, In-Ja, Koshino, Hiroyuki, Yoo, Ick-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	6-HYDROXY-1H-INDOLE-3-ACETAMIDE 6-HYDROXY-1H-INDOLE-3-CARBOXALDEHYDE AGROCYBE Animals ANTIOXIDANTES ANTIOXIDANTS ANTIOXYDANT Basidiomycota - chemistry Biological and medical sciences CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE CYTOPLASMIC ORGANELLES ESPECTROMETRIA ESTRUCTURA QUIMICA Free Radical Scavengers - pharmacology FREE RADICALS General pharmacology INDOL INDOLES Indoles - chemistry Indoles - pharmacology INHIBICION INHIBITION LIPID PEROXIDATION Lipid Peroxidation - drug effects Medical sciences MICELIO MICROSOMES Microsomes, Liver - drug effects Microsomes, Liver - metabolism MYCELIUM ORGANITE CELLULAIRE ORGANULOS CITOPLASMICOS PEROXIDACION LIPIDICA PEROXYDATION DES LIPIDES Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments RADICAL LIBRE RADICALES LIBRES RAT RATA RATS SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY Spectrum Analysis STRUCTURE CHIMIQUE
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Zusammenfassung:	Two new indole derivatives were isolated as free radical scavengers from the MeOH extract of Agrocybe cylindracea. The structures of these compounds were determined to be 6-hydroxy-1H-indole-3-carboxaldehyde (1) and 6-hydroxy-1H-indole-3-acetamide (2) on the basis of spectroscopic studies. Compounds 1 and 2 inhibited lipid peroxidation in rat liver microsomes, with IC50 values of 4.1 and 3.9 μg/mL, respectively.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np970150w