1,3-Dimethylisoguanine, a New Purine from the Marine Sponge Amphimedon viridis
A new purine, 1,3-dimethylisoguanine (1), has been isolated from the marine sponge Amphimedon viridis and identified by analysis of spectroscopic data. Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1997-07, Vol.60 (7), p.729-731 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 60 |
| creator | Chehade, Claire C Dias, Ricardo L. A Berlinck, Roberto G. S Ferreira, Antonio G Costa, Letícia V Rangel, Marisa Malpezzi, Elena L. A de Freitas, José Carlos Hajdu, Eduardo |
| description | A new purine, 1,3-dimethylisoguanine (1), has been isolated from the marine sponge Amphimedon viridis and identified by analysis of spectroscopic data. Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose-dependent manner. |
| doi_str_mv | 10.1021/np970021f |
| format | Article |
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A ; Berlinck, Roberto G. S ; Ferreira, Antonio G ; Costa, Letícia V ; Rangel, Marisa ; Malpezzi, Elena L. A ; de Freitas, José Carlos ; Hajdu, Eduardo</creator><creatorcontrib>Chehade, Claire C ; Dias, Ricardo L. A ; Berlinck, Roberto G. S ; Ferreira, Antonio G ; Costa, Letícia V ; Rangel, Marisa ; Malpezzi, Elena L. A ; de Freitas, José Carlos ; Hajdu, Eduardo</creatorcontrib><description>A new purine, 1,3-dimethylisoguanine (1), has been isolated from the marine sponge Amphimedon viridis and identified by analysis of spectroscopic data. Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose-dependent manner.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np970021f</identifier><identifier>PMID: 9249981</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Amphimedon viridis ; Animals ; Biological and medical sciences ; BRASIL ; BRAZIL ; BRESIL ; CHEMICAL COMPOSITION ; CHEMICAL STRUCTURE ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; DERIVATIVES ; Electric Stimulation ; EPONGE ; ESPECTROMETRIA ; ESPONJAS ; ESTRUCTURA QUIMICA ; General pharmacology ; GUANINA ; GUANINE ; Guanine - analogs & derivatives ; Guanine - chemistry ; Guanine - isolation & purification ; Guanine - pharmacology ; Guinea Pigs ; In Vitro Techniques ; Marine ; Medical sciences ; MUSCLE ; MUSCLE CONTRACTION ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; MUSCLES ; MUSCULOS ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Porifera ; Porifera - chemistry ; PURINAS ; PURINE ; PURINES ; REGULATION ; SPECTRAL ANALYSIS ; SPECTROMETRIE ; SPECTROMETRY ; SPONGES ; STRUCTURE CHIMIQUE</subject><ispartof>Journal of natural products (Washington, D.C.), 1997-07, Vol.60 (7), p.729-731</ispartof><rights>Copyright © 1997 American Chemical Society and American Society of Pharmacognosy</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a493t-759aba9e5016eafcf0b230de9e9960ae0f699ebefba35f4f285ac10e26f9ff0c3</citedby><cites>FETCH-LOGICAL-a493t-759aba9e5016eafcf0b230de9e9960ae0f699ebefba35f4f285ac10e26f9ff0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np970021f$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np970021f$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2759418$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9249981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chehade, Claire C</creatorcontrib><creatorcontrib>Dias, Ricardo L. A</creatorcontrib><creatorcontrib>Berlinck, Roberto G. S</creatorcontrib><creatorcontrib>Ferreira, Antonio G</creatorcontrib><creatorcontrib>Costa, Letícia V</creatorcontrib><creatorcontrib>Rangel, Marisa</creatorcontrib><creatorcontrib>Malpezzi, Elena L. A</creatorcontrib><creatorcontrib>de Freitas, José Carlos</creatorcontrib><creatorcontrib>Hajdu, Eduardo</creatorcontrib><title>1,3-Dimethylisoguanine, a New Purine from the Marine Sponge Amphimedon viridis</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>A new purine, 1,3-dimethylisoguanine (1), has been isolated from the marine sponge Amphimedon viridis and identified by analysis of spectroscopic data. Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose-dependent manner.</description><subject>Amphimedon viridis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BRASIL</subject><subject>BRAZIL</subject><subject>BRESIL</subject><subject>CHEMICAL COMPOSITION</subject><subject>CHEMICAL STRUCTURE</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>DERIVATIVES</subject><subject>Electric Stimulation</subject><subject>EPONGE</subject><subject>ESPECTROMETRIA</subject><subject>ESPONJAS</subject><subject>ESTRUCTURA QUIMICA</subject><subject>General pharmacology</subject><subject>GUANINA</subject><subject>GUANINE</subject><subject>Guanine - analogs & derivatives</subject><subject>Guanine - chemistry</subject><subject>Guanine - isolation & purification</subject><subject>Guanine - pharmacology</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Marine</subject><subject>Medical sciences</subject><subject>MUSCLE</subject><subject>MUSCLE CONTRACTION</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>MUSCLES</subject><subject>MUSCULOS</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Porifera</subject><subject>Porifera - chemistry</subject><subject>PURINAS</subject><subject>PURINE</subject><subject>PURINES</subject><subject>REGULATION</subject><subject>SPECTRAL ANALYSIS</subject><subject>SPECTROMETRIE</subject><subject>SPECTROMETRY</subject><subject>SPONGES</subject><subject>STRUCTURE CHIMIQUE</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v1DAQxS0EKsvCgSsSUg4FCamBsR0n8bFaoCAtpWjbszXJjndd8oWdAP3vcclqT0jIB3v0fn568xh7zuEtB8HfdYMuID7sA7bgSkCag1AP2QJ4LlNZ5tlj9iSEWwCQoNUJO9Ei07rkC3bJz2T63rU07u8aF_rdhJ3r6CzB5JJ-JVeTj1Nifd8m456SL_h33gx9t6PkvB328eu275KfzrutC0_ZI4tNoGeHe8luPn64Xn1K118vPq_O1ylmWo5poTRWqEnFgIS2tlAJCVvSpHUOSGBzrakiW6FUNrOiVFhzIJFbbS3Ucslez76D739MFEbTulBT02BH_RRMoXkpcyX-C_JcqAIURPDNDNa-D8GTNYN3Lfo7w8Hcl2yOJUf25cF0quL6R_LQatRPDzqGGhvrsatdOGIirp_FfEuWzpgLI_0-yui_m7yQhTLXVxuTlWu1upDfzL3ti5m32Bvc-Wh5s9FFxuOJ4qtZxDqY237yXez_H9n_ABvnpog</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>Chehade, Claire C</creator><creator>Dias, Ricardo L. A</creator><creator>Berlinck, Roberto G. S</creator><creator>Ferreira, Antonio G</creator><creator>Costa, Letícia V</creator><creator>Rangel, Marisa</creator><creator>Malpezzi, Elena L. A</creator><creator>de Freitas, José Carlos</creator><creator>Hajdu, Eduardo</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>1,3-Dimethylisoguanine, a New Purine from the Marine Sponge Amphimedon viridis</title><author>Chehade, Claire C ; Dias, Ricardo L. A ; Berlinck, Roberto G. S ; Ferreira, Antonio G ; Costa, Letícia V ; Rangel, Marisa ; Malpezzi, Elena L. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Porifera</topic><topic>Porifera - chemistry</topic><topic>PURINAS</topic><topic>PURINE</topic><topic>PURINES</topic><topic>REGULATION</topic><topic>SPECTRAL ANALYSIS</topic><topic>SPECTROMETRIE</topic><topic>SPECTROMETRY</topic><topic>SPONGES</topic><topic>STRUCTURE CHIMIQUE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chehade, Claire C</creatorcontrib><creatorcontrib>Dias, Ricardo L. A</creatorcontrib><creatorcontrib>Berlinck, Roberto G. S</creatorcontrib><creatorcontrib>Ferreira, Antonio G</creatorcontrib><creatorcontrib>Costa, Letícia V</creatorcontrib><creatorcontrib>Rangel, Marisa</creatorcontrib><creatorcontrib>Malpezzi, Elena L. 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Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose-dependent manner.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>9249981</pmid><doi>10.1021/np970021f</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1997-07, Vol.60 (7), p.729-731 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Amphimedon viridis Animals Biological and medical sciences BRASIL BRAZIL BRESIL CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE DERIVATIVES Electric Stimulation EPONGE ESPECTROMETRIA ESPONJAS ESTRUCTURA QUIMICA General pharmacology GUANINA GUANINE Guanine - analogs & derivatives Guanine - chemistry Guanine - isolation & purification Guanine - pharmacology Guinea Pigs In Vitro Techniques Marine Medical sciences MUSCLE MUSCLE CONTRACTION Muscle Contraction - drug effects Muscle Contraction - physiology MUSCLES MUSCULOS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera Porifera - chemistry PURINAS PURINE PURINES REGULATION SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY SPONGES STRUCTURE CHIMIQUE |
| title | 1,3-Dimethylisoguanine, a New Purine from the Marine Sponge Amphimedon viridis |
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