1,3-Dimethylisoguanine, a New Purine from the Marine Sponge Amphimedon viridis

A new purine, 1,3-dimethylisoguanine (1), has been isolated from the marine sponge Amphimedon viridis and identified by analysis of spectroscopic data. Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-07, Vol.60 (7), p.729-731
Hauptverfasser:	Chehade, Claire C, Dias, Ricardo L. A, Berlinck, Roberto G. S, Ferreira, Antonio G, Costa, Letícia V, Rangel, Marisa, Malpezzi, Elena L. A, de Freitas, José Carlos, Hajdu, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphimedon viridis Animals Biological and medical sciences BRASIL BRAZIL BRESIL CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE DERIVATIVES Electric Stimulation EPONGE ESPECTROMETRIA ESPONJAS ESTRUCTURA QUIMICA General pharmacology GUANINA GUANINE Guanine - analogs & derivatives Guanine - chemistry Guanine - isolation & purification Guanine - pharmacology Guinea Pigs In Vitro Techniques Marine Medical sciences MUSCLE MUSCLE CONTRACTION Muscle Contraction - drug effects Muscle Contraction - physiology MUSCLES MUSCULOS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera Porifera - chemistry PURINAS PURINE PURINES REGULATION SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY SPONGES STRUCTURE CHIMIQUE
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Beschreibung
Zusammenfassung:	A new purine, 1,3-dimethylisoguanine (1), has been isolated from the marine sponge Amphimedon viridis and identified by analysis of spectroscopic data. Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose-dependent manner.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np970021f