Cholinergic neuromodulation by endothelin in guinea pig ileum

The effect of endothelin on cholinergic neuroeffector transmission in guinea pig ileum was investigated. Endothelin was shown to inhibit the nerve-induced contractions and concomitantly to increase the basal muscle tone. Furthermore, endothelin inhibited the nerve-induced release of [ 3H]acetylcholi...

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Veröffentlicht in:	Neuroscience letters 1989-07, Vol.101 (3), p.342-346
Hauptverfasser:	Wiklund, N.Peter, Wiklund, Claes U., Öhlén, Anders, Gustafsson, Lars E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacokinetics Acetylcholine release Animals Biological and medical sciences Cell physiology Cholinergic Fibers - drug effects Cholinergic Fibers - metabolism Cholinergic Fibers - physiology Electric Stimulation Endothelin Endothelins Female Fundamental and applied biological sciences. Psychology Guinea pig Guinea Pigs Ileum Ileum - innervation In Vitro Techniques Male Molecular and cellular biology Muscle contraction Muscle Contraction - drug effects Neurotransmission Peptides - pharmacology Smooth muscle Synaptic Transmission - drug effects Vasoconstrictor Agents - pharmacology
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Zusammenfassung:	The effect of endothelin on cholinergic neuroeffector transmission in guinea pig ileum was investigated. Endothelin was shown to inhibit the nerve-induced contractions and concomitantly to increase the basal muscle tone. Furthermore, endothelin inhibited the nerve-induced release of [ 3H]acetylcholine whereas the contractile response to exogenous acetylcholine was enhanced. In conclusion, our findings suggest that endothelin is a modulator of cholinergic neuroeffector transmission in guinea pig ileum with possible action via both inhibitory prejunctional and stimulatory postjunctional mechanisms.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(89)90557-0