Determination of false negative rate in fine-needle aspiration of prostate: Study of sequential aspirations in 30 untreated carcinoma patients
Despite several studies comparing the diagnostic, accuracy of core needle biopsy and fine-needle aspiration (FNA) in the diagnosis of prostatic adenocareinoma, no clear picture of the false negative rate for FNA is available. We studied 101 follow-up FNA evaluations in 30 patients with untreated wel...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 1989-08, Vol.34 (2), p.73-75 |
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| container_title | Urology (Ridgewood, N.J.) |
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| creator | Stanley, Michael W. Hedlund, Per Olov Rönstrom, Lars Esposti, Pier Luigi Löwhagen, Torsten |
| description | Despite several studies comparing the diagnostic, accuracy of core needle biopsy and fine-needle aspiration (FNA) in the diagnosis of prostatic adenocareinoma, no clear picture of the false negative rate for FNA is available. We studied 101 follow-up FNA evaluations in 30 patients with untreated well-differentiated carcinoma. The patients were followed for a median of two years and seven months and had from two to seven FNA follow-up evaluations (median = 2.5 evaluations per patient). If three inadequate evaluations are omitted, the combined rate of positive plus suspicious FNA biopsies was 92.9 percent (88.8 % plus 4.1 %, respectively). The residual false negative rate was 7.1 percent. The clinical features and follow-up data are described. A semiquantitative definition of “suspicious for malignancy” is suggested. We conclude that in experienced hands. FNA is a highly efficacious method for the diagnosis of prostatic adenocarcinoma. |
| doi_str_mv | 10.1016/0090-4295(89)90166-0 |
| format | Article |
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We studied 101 follow-up FNA evaluations in 30 patients with untreated well-differentiated carcinoma. The patients were followed for a median of two years and seven months and had from two to seven FNA follow-up evaluations (median = 2.5 evaluations per patient). If three inadequate evaluations are omitted, the combined rate of positive plus suspicious FNA biopsies was 92.9 percent (88.8 % plus 4.1 %, respectively). The residual false negative rate was 7.1 percent. The clinical features and follow-up data are described. A semiquantitative definition of “suspicious for malignancy” is suggested. We conclude that in experienced hands. FNA is a highly efficacious method for the diagnosis of prostatic adenocarcinoma.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/0090-4295(89)90166-0</identifier><identifier>PMID: 2763402</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenocarcinoma - pathology ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biopsy, Needle ; False Negative Reactions ; Follow-Up Studies ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Predictive Value of Tests ; Prostate - pathology ; Prostatic Neoplasms - pathology ; Urinary system</subject><ispartof>Urology (Ridgewood, N.J.), 1989-08, Vol.34 (2), p.73-75</ispartof><rights>1989</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0090429589901660$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19635458$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2763402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stanley, Michael W.</creatorcontrib><creatorcontrib>Hedlund, Per Olov</creatorcontrib><creatorcontrib>Rönstrom, Lars</creatorcontrib><creatorcontrib>Esposti, Pier Luigi</creatorcontrib><creatorcontrib>Löwhagen, Torsten</creatorcontrib><title>Determination of false negative rate in fine-needle aspiration of prostate: Study of sequential aspirations in 30 untreated carcinoma patients</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>Despite several studies comparing the diagnostic, accuracy of core needle biopsy and fine-needle aspiration (FNA) in the diagnosis of prostatic adenocareinoma, no clear picture of the false negative rate for FNA is available. We studied 101 follow-up FNA evaluations in 30 patients with untreated well-differentiated carcinoma. The patients were followed for a median of two years and seven months and had from two to seven FNA follow-up evaluations (median = 2.5 evaluations per patient). If three inadequate evaluations are omitted, the combined rate of positive plus suspicious FNA biopsies was 92.9 percent (88.8 % plus 4.1 %, respectively). The residual false negative rate was 7.1 percent. The clinical features and follow-up data are described. A semiquantitative definition of “suspicious for malignancy” is suggested. We conclude that in experienced hands. FNA is a highly efficacious method for the diagnosis of prostatic adenocarcinoma.</description><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>False Negative Reactions</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Predictive Value of Tests</subject><subject>Prostate - pathology</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Urinary system</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkcuKFTEQhoMo45nRN1DIRtFFayWdTne5EGTGGwy4UNchJ6mWSHf6mKQH5iV8ZtMzh4Orgr--uv6MPRPwRoDQbwEQGiWxezXga6yKbuAB24lO9g0idg_Z7oQ8Zuc5_wYArXV_xs5kr1sFcsf-XlGhNIdoS1giX0Y-2ikTj_SrKjfEky3EQ-RjiNREIj8Rt_kQ0qngkJZcKvWOfy-rv92kTH9WiiXY6T82b21a4GssiSrvubPJhbjMlh8qUQvyE_bobv7TY7xgPz99_HH5pbn-9vnr5YfrhiSK0pBuUTrnsMOxk6Mi1SJ5Nyr0g8aBrBTCq3HYgxI97Futycn6E62UFwL69oK9vO9bl6-r5mLmkB1Nk420rNn0KHSnASr4_Aiu-5m8OaQw23Rrjg-s-RfHvM3OTmOy0YV8wgTqtlPdULn39xzVq24CJZNdvdiRD4lcMX4JRoDZjDWba2ZzzQxo7ow10P4DXKKWDQ</recordid><startdate>19890801</startdate><enddate>19890801</enddate><creator>Stanley, Michael W.</creator><creator>Hedlund, Per Olov</creator><creator>Rönstrom, Lars</creator><creator>Esposti, Pier Luigi</creator><creator>Löwhagen, Torsten</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19890801</creationdate><title>Determination of false negative rate in fine-needle aspiration of prostate: Study of sequential aspirations in 30 untreated carcinoma patients</title><author>Stanley, Michael W. ; Hedlund, Per Olov ; Rönstrom, Lars ; Esposti, Pier Luigi ; Löwhagen, Torsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e291t-e6392ccc959f52f4e439edcf49d8698ea211d4f8b04170b366ec2999644d11073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>False Negative Reactions</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Predictive Value of Tests</topic><topic>Prostate - pathology</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stanley, Michael W.</creatorcontrib><creatorcontrib>Hedlund, Per Olov</creatorcontrib><creatorcontrib>Rönstrom, Lars</creatorcontrib><creatorcontrib>Esposti, Pier Luigi</creatorcontrib><creatorcontrib>Löwhagen, Torsten</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stanley, Michael W.</au><au>Hedlund, Per Olov</au><au>Rönstrom, Lars</au><au>Esposti, Pier Luigi</au><au>Löwhagen, Torsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of false negative rate in fine-needle aspiration of prostate: Study of sequential aspirations in 30 untreated carcinoma patients</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>34</volume><issue>2</issue><spage>73</spage><epage>75</epage><pages>73-75</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>Despite several studies comparing the diagnostic, accuracy of core needle biopsy and fine-needle aspiration (FNA) in the diagnosis of prostatic adenocareinoma, no clear picture of the false negative rate for FNA is available. We studied 101 follow-up FNA evaluations in 30 patients with untreated well-differentiated carcinoma. The patients were followed for a median of two years and seven months and had from two to seven FNA follow-up evaluations (median = 2.5 evaluations per patient). If three inadequate evaluations are omitted, the combined rate of positive plus suspicious FNA biopsies was 92.9 percent (88.8 % plus 4.1 %, respectively). The residual false negative rate was 7.1 percent. The clinical features and follow-up data are described. A semiquantitative definition of “suspicious for malignancy” is suggested. We conclude that in experienced hands. FNA is a highly efficacious method for the diagnosis of prostatic adenocarcinoma.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2763402</pmid><doi>10.1016/0090-4295(89)90166-0</doi><tpages>3</tpages></addata></record> |
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| subjects | Adenocarcinoma - pathology Aged Aged, 80 and over Biological and medical sciences Biopsy, Needle False Negative Reactions Follow-Up Studies Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Predictive Value of Tests Prostate - pathology Prostatic Neoplasms - pathology Urinary system |
| title | Determination of false negative rate in fine-needle aspiration of prostate: Study of sequential aspirations in 30 untreated carcinoma patients |
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