Hypothalamic sites of neuronal histamine action on food intake by rats

To identify sites of histaminergic modulation of food intake, histamine H 1-receptor antagonist was microinfused into the rat hypothalamus, the ventromedial hypothalamus (VMH), the lateral hypothalamus (LHA), the paraventricular nucleus (PVN), the dorsomedial hypothalamus (DMH), or the preoptic ante...

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Veröffentlicht in:	Brain research 1989-06, Vol.490 (2), p.268-275
Hauptverfasser:	Ookuma, Kazuyoshi, Yoshimatsu, Hironobu, Sakata, Toshiie, Fujimoto, Kazuma, Fukagawa, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihistamine, H 1 Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Chlorpheniramine - pharmacology Dose-Response Relationship, Drug Feeding Feeding Behavior - drug effects Fundamental and applied biological sciences. Psychology Histamine - physiology Histamine H 1-receptor Hypothalamus - drug effects Hypothalamus - physiology Male Microinfusion Paraventricular nucleus Rats Rats, Inbred Strains Receptors, Histamine - drug effects Receptors, Histamine - physiology Ventromedial nucleus Vertebrates: nervous system and sense organs α-Fluoromethylhistidine
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Zusammenfassung:	To identify sites of histaminergic modulation of food intake, histamine H 1-receptor antagonist was microinfused into the rat hypothalamus, the ventromedial hypothalamus (VMH), the lateral hypothalamus (LHA), the paraventricular nucleus (PVN), the dorsomedial hypothalamus (DMH), or the preoptic anterior hypothalamus (POAH), during the early light period. Feeding, but not drinking, was elicited in 100% of the rats ( P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(89)90244-8