Structure and function of pancreatic lipase and colipase

Dietary fats are essential for life and good health. Efficient absorption of dietary fats is dependent on the action of pancreatic triglyceride lipase. In the last few years, large advances have been made in describing the structure and lipolytic mechanism of human pancreatic triglyceride lipase and...

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Veröffentlicht in:	Annual review of nutrition 1997-01, Vol.17 (1), p.141-158
1. Verfasser:	Lowe, M.E
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTIVIDAD CATALITICA ACTIVIDAD ENZIMATICA ACTIVITE CATALYTIQUE ACTIVITE ENZYMATIQUE ADN Analytical, structural and metabolic biochemistry Binding Sites Biological and medical sciences CATALYTIC ACTIVITY CHEMICAL STRUCTURE Colipases - chemistry Colipases - metabolism COMPLEMENTARY DNA DNA Enzymes and enzyme inhibitors Enzymes. Coenzymes. Vitamins. Pigments ENZYMIC ACTIVITY ESTRUCTURA QUIMICA FISIOLOGIA DE LA NUTRICION Fundamental and applied biological sciences. Psychology Humans Hydrolases INTERFACE INTERFACE PHENOMENA INTERFACIAL ACTIVITY Lipase - chemistry Lipase - metabolism LIPOLISIS LIPOLYSE LIPOLYSIS LITERATURE REVIEWS Metabolisms and neurohumoral controls MODE OF ACTION MODELE MODELOS MOLECULAR CONFORMATION Molecular Structure NUTRITION PHYSIOLOGY PANCREAS Pancreas - enzymology PHENOMENE D'INTERFACE PHYSIOLOGIE DE LA NUTRITION STRUCTURE CHIMIQUE Structure-Activity Relationship TRIACILGLICEROL LIPASA TRIACYLGLYCEROL LIPASE Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Beschreibung
Zusammenfassung:	Dietary fats are essential for life and good health. Efficient absorption of dietary fats is dependent on the action of pancreatic triglyceride lipase. In the last few years, large advances have been made in describing the structure and lipolytic mechanism of human pancreatic triglyceride lipase and of colipase, another pancreatic protein that interacts with pancreatic triglyceride lipase and that is required for lipase activity in the duodenum. This review discusses the advances made in protein structure and in understanding the relationships of structure to function of pancreatic triglyceride lipase and colipase
ISSN:	0199-9885 1545-4312
DOI:	10.1146/annurev.nutr.17.1.141