Verification and comparison of two different predictive equations in Hodgkin's disease

Divisione di Medicina Generale, Ospedale F. Del Ponte, Varese, Italy. BACKGROUND AND OBJECTIVE: In recent years, two predictive equations to estimate median expected survival at diagnosis for patients affected with Hodgkin's disease have been developed at the University of Pavia Medical School. The present retrospective work was aimed at testing correlation between mean survival estimated using the two equations and observed survival, and at comparing the results of the two different equations. METHODS: Fifty-three deceased patients were considered from a series of 114 consecutive ones. All these patients had been treated in a conventional way according to therapeutic modalities similar to those used in the series from which the two equations were derived. Expected median survival values calculated with the older, linear equation and with the newer exponential one were compared with observed survival. RESULTS: Mean survival of the whole series was over 24 years, with survival probabilities of 85% after 5 years and 74% after 10 years. Using the first predictive equation on the 53 deceased patients resulted in a satisfactory correlation between estimated median survival and real survival: Pearson's R correlation coefficient value is 0.5996, with a t value of 5.35 and p